W. T. Shier, D. J. DuBourdieu and H. Kawaguchi. Selection for resistance to phallolysin, a cytolytic toxin from the death-cap mushroom (Amanita phalloides), Toxicon 21, 447 - 450, 1983. - Phallolysin-resistant variants are readily selected from unmutagenized populations of mouse fibroblasts. They exhibit partial cross-resistance to wheat germ agglutinin, a lectin with a saccharide specificity similar to phallolysin. These results are consistent with phallolysin acting by binding to cell surface glycoprotein receptors rather than by interacting directly with lipid components of the membrane.
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Acknowledgements -These studies were supported by NSF grant PCM 80-11784, and by a fellowship from the Japan Educational Fund (to H .K.) . We gratefully acknowledge the gift of purified phallolysin from Professor RurH SEEGER, without which this work would not have been possible, and valuable discussions with Dr . J . P . DuRKw. Some initial studies in this work were carried out at the Salk Institute, San Diego, CA, U .S .A.
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