Selection for resistance to phallolysin, a cytolytic toxin from the death-cap mushroom (Amanita phalloides)

W. T. Shier, D. J. DuBourdieu, H. Kawaguchi

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4 Scopus citations

Abstract

W. T. Shier, D. J. DuBourdieu and H. Kawaguchi. Selection for resistance to phallolysin, a cytolytic toxin from the death-cap mushroom (Amanita phalloides), Toxicon 21, 447 - 450, 1983. - Phallolysin-resistant variants are readily selected from unmutagenized populations of mouse fibroblasts. They exhibit partial cross-resistance to wheat germ agglutinin, a lectin with a saccharide specificity similar to phallolysin. These results are consistent with phallolysin acting by binding to cell surface glycoprotein receptors rather than by interacting directly with lipid components of the membrane.

Original languageEnglish (US)
Pages (from-to)445-448
Number of pages4
JournalToxicon
Volume21
Issue number3
DOIs
StatePublished - 1983

Bibliographical note

Funding Information:
Acknowledgements -These studies were supported by NSF grant PCM 80-11784, and by a fellowship from the Japan Educational Fund (to H .K.) . We gratefully acknowledge the gift of purified phallolysin from Professor RurH SEEGER, without which this work would not have been possible, and valuable discussions with Dr . J . P . DuRKw. Some initial studies in this work were carried out at the Salk Institute, San Diego, CA, U .S .A.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

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