Select Dietary Phytochemicals Function as Inhibitors of COX-1 but Not COX-2

Haitao Li, Feng Zhu, Yanwen Sun, Bing Li, Naomi Oi, Hanyong Chen, Ronald A. Lubet, Ann M. Bode, Zigang Dong

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Recent clinical trials raised concerns regarding the cardiovascular toxicity of selective cyclooxygenase-2 (COX-2) inhibitors. Many active dietary factors are reported to suppress carcinogenesis by targeting COX-2. A major question was accordingly raised: why has the lifelong use of phytochemicals that likely inhibit COX-2 presumably not been associated with adverse cardiovascular side effects. To answer this question, we selected a library of dietary-derived phytochemicals and evaluated their potential cardiovascular toxicity in human umbilical vein endothelial cells. Our data indicated that the possibility of cardiovascular toxicity of these dietary phytochemicals was low. Further mechanistic studies revealed that the actions of these phytochemicals were similar to aspirin in that they mainly inhibited COX-1 rather than COX-2, especially at low doses.

Original languageEnglish (US)
Article numbere76452
JournalPloS one
Volume8
Issue number10
DOIs
StatePublished - Oct 3 2013

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