Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300

Chinmay Y. Majmudar, Jonas W. Højfeldt, Carl J. Arevang, William C. Pomerantz, Jessica K. Gagnon, Pamela J. Schultz, Laura C. Cesa, Conor H. Doss, Steven P. Rowe, Victor Vásquez, Giselle Tamayo-Castillo, Tomasz Cierpicki, Charles L. Brooks, David H. Sherman, Anna K. Mapp

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Capturing a coactivator, naturally: The natural products sekikaic acid and lobaric acid, isolated after a high-throughput screen of a structurally diverse extract collection, effectively target the dynamic binding interfaces of the GACKIX domain of the coactivator CBP/p300 (see structure). These molecules are the most effective inhibitors of the GACKIX domain yet described and are uniquely selective for this domain.

Original languageEnglish (US)
Pages (from-to)11258-11262
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number45
DOIs
StatePublished - Nov 5 2012
Externally publishedYes

Fingerprint

p300-CBP Transcription Factors
Biological Products
Throughput
Molecules
Acids
lobaric acid

Keywords

  • coactivators
  • depsides
  • inhibitors
  • protein-protein interactions
  • sekikaic acid

Cite this

Majmudar, C. Y., Højfeldt, J. W., Arevang, C. J., Pomerantz, W. C., Gagnon, J. K., Schultz, P. J., ... Mapp, A. K. (2012). Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300. Angewandte Chemie - International Edition, 51(45), 11258-11262. https://doi.org/10.1002/anie.201206815

Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300. / Majmudar, Chinmay Y.; Højfeldt, Jonas W.; Arevang, Carl J.; Pomerantz, William C.; Gagnon, Jessica K.; Schultz, Pamela J.; Cesa, Laura C.; Doss, Conor H.; Rowe, Steven P.; Vásquez, Victor; Tamayo-Castillo, Giselle; Cierpicki, Tomasz; Brooks, Charles L.; Sherman, David H.; Mapp, Anna K.

In: Angewandte Chemie - International Edition, Vol. 51, No. 45, 05.11.2012, p. 11258-11262.

Research output: Contribution to journalArticle

Majmudar, CY, Højfeldt, JW, Arevang, CJ, Pomerantz, WC, Gagnon, JK, Schultz, PJ, Cesa, LC, Doss, CH, Rowe, SP, Vásquez, V, Tamayo-Castillo, G, Cierpicki, T, Brooks, CL, Sherman, DH & Mapp, AK 2012, 'Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300', Angewandte Chemie - International Edition, vol. 51, no. 45, pp. 11258-11262. https://doi.org/10.1002/anie.201206815
Majmudar, Chinmay Y. ; Højfeldt, Jonas W. ; Arevang, Carl J. ; Pomerantz, William C. ; Gagnon, Jessica K. ; Schultz, Pamela J. ; Cesa, Laura C. ; Doss, Conor H. ; Rowe, Steven P. ; Vásquez, Victor ; Tamayo-Castillo, Giselle ; Cierpicki, Tomasz ; Brooks, Charles L. ; Sherman, David H. ; Mapp, Anna K. / Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300. In: Angewandte Chemie - International Edition. 2012 ; Vol. 51, No. 45. pp. 11258-11262.
@article{15ba59fbf3ef46de947c5aa4649deb33,
title = "Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300",
abstract = "Capturing a coactivator, naturally: The natural products sekikaic acid and lobaric acid, isolated after a high-throughput screen of a structurally diverse extract collection, effectively target the dynamic binding interfaces of the GACKIX domain of the coactivator CBP/p300 (see structure). These molecules are the most effective inhibitors of the GACKIX domain yet described and are uniquely selective for this domain.",
keywords = "coactivators, depsides, inhibitors, protein-protein interactions, sekikaic acid",
author = "Majmudar, {Chinmay Y.} and H{\o}jfeldt, {Jonas W.} and Arevang, {Carl J.} and Pomerantz, {William C.} and Gagnon, {Jessica K.} and Schultz, {Pamela J.} and Cesa, {Laura C.} and Doss, {Conor H.} and Rowe, {Steven P.} and Victor V{\'a}squez and Giselle Tamayo-Castillo and Tomasz Cierpicki and Brooks, {Charles L.} and Sherman, {David H.} and Mapp, {Anna K.}",
year = "2012",
month = "11",
day = "5",
doi = "10.1002/anie.201206815",
language = "English (US)",
volume = "51",
pages = "11258--11262",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "45",

}

TY - JOUR

T1 - Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300

AU - Majmudar, Chinmay Y.

AU - Højfeldt, Jonas W.

AU - Arevang, Carl J.

AU - Pomerantz, William C.

AU - Gagnon, Jessica K.

AU - Schultz, Pamela J.

AU - Cesa, Laura C.

AU - Doss, Conor H.

AU - Rowe, Steven P.

AU - Vásquez, Victor

AU - Tamayo-Castillo, Giselle

AU - Cierpicki, Tomasz

AU - Brooks, Charles L.

AU - Sherman, David H.

AU - Mapp, Anna K.

PY - 2012/11/5

Y1 - 2012/11/5

N2 - Capturing a coactivator, naturally: The natural products sekikaic acid and lobaric acid, isolated after a high-throughput screen of a structurally diverse extract collection, effectively target the dynamic binding interfaces of the GACKIX domain of the coactivator CBP/p300 (see structure). These molecules are the most effective inhibitors of the GACKIX domain yet described and are uniquely selective for this domain.

AB - Capturing a coactivator, naturally: The natural products sekikaic acid and lobaric acid, isolated after a high-throughput screen of a structurally diverse extract collection, effectively target the dynamic binding interfaces of the GACKIX domain of the coactivator CBP/p300 (see structure). These molecules are the most effective inhibitors of the GACKIX domain yet described and are uniquely selective for this domain.

KW - coactivators

KW - depsides

KW - inhibitors

KW - protein-protein interactions

KW - sekikaic acid

UR - http://www.scopus.com/inward/record.url?scp=84868104231&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868104231&partnerID=8YFLogxK

U2 - 10.1002/anie.201206815

DO - 10.1002/anie.201206815

M3 - Article

C2 - 23042634

AN - SCOPUS:84868104231

VL - 51

SP - 11258

EP - 11262

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 45

ER -