Seizure source imaging by means of FINE spatio-temporal dipole localization and directed transfer function in partial epilepsy patients

Yunfeng Lu; Lin Yang; Gregory A. Worrell; Bin He

doi:10.1016/j.clinph.2011.11.007

Seizure source imaging by means of FINE spatio-temporal dipole localization and directed transfer function in partial epilepsy patients

Yunfeng Lu, Lin Yang, Gregory A. Worrell, Bin He

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

Objective: To investigate the usage of a high-density EEG recording system and source imaging technique for localizing seizure activity in patients with medically intractable partial epilepsy. Methods: High-density, 76-channel scalp EEG signals were recorded in 10 patients with partial epilepsy. The patients underwent routine clinical pre-surgical evaluation and all had resective surgery with seizure free outcome. After applying a FINE (first principle vectors) spatio-temporal source localization and DTF (directed transfer function) connectivity analysis approach, ictal sources were imaged. Effects of number of scalp EEG electrodes on the seizure localization were also assessed using 76, 64, 48, 32, and 21 electrodes, respectively. Results: Surgical resections were used to assess the source imaging results. Results from the 76-channel EEG in the 10 patients showed high correlation with the surgically resected brain regions. The localization of seizure onset zone from 76-channel EEG showed improved source detection accuracy compared to other EEG configurations with fewer electrodes. Conclusions: FINE together with DTF was able to localize seizure onset zones of partial epilepsy patients. High-density EEG recording can help achieve improved seizure source imaging. Significance: The present results suggest the promise of high-density EEG and electrical source imaging for noninvasively localizing seizure onset zones.

Original language	English (US)
Pages (from-to)	1275-1283
Number of pages	9
Journal	Clinical Neurophysiology
Volume	123
Issue number	7
DOIs	https://doi.org/10.1016/j.clinph.2011.11.007
State	Published - Jul 2012

Bibliographical note

Funding Information:
This work was supported in part by NIH RO1 EB007920 and RO1 EB006433 and a grant from the Minnesota Partnership for Biotechnology and Medical Genomics . The authors thank Cindy Nelson for technical assistance in data collection, and Dr. Benjamin Brinkmann for assistance in data mining.

Keywords

Directed transfer function
EEG source imaging
Epilepsy
FINE
High-density EEG
Ictal activities

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10.1016/j.clinph.2011.11.007

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title = "Seizure source imaging by means of FINE spatio-temporal dipole localization and directed transfer function in partial epilepsy patients",

abstract = "Objective: To investigate the usage of a high-density EEG recording system and source imaging technique for localizing seizure activity in patients with medically intractable partial epilepsy. Methods: High-density, 76-channel scalp EEG signals were recorded in 10 patients with partial epilepsy. The patients underwent routine clinical pre-surgical evaluation and all had resective surgery with seizure free outcome. After applying a FINE (first principle vectors) spatio-temporal source localization and DTF (directed transfer function) connectivity analysis approach, ictal sources were imaged. Effects of number of scalp EEG electrodes on the seizure localization were also assessed using 76, 64, 48, 32, and 21 electrodes, respectively. Results: Surgical resections were used to assess the source imaging results. Results from the 76-channel EEG in the 10 patients showed high correlation with the surgically resected brain regions. The localization of seizure onset zone from 76-channel EEG showed improved source detection accuracy compared to other EEG configurations with fewer electrodes. Conclusions: FINE together with DTF was able to localize seizure onset zones of partial epilepsy patients. High-density EEG recording can help achieve improved seizure source imaging. Significance: The present results suggest the promise of high-density EEG and electrical source imaging for noninvasively localizing seizure onset zones.",

keywords = "Directed transfer function, EEG source imaging, Epilepsy, FINE, High-density EEG, Ictal activities",

author = "Yunfeng Lu and Lin Yang and Worrell, {Gregory A.} and Bin He",

note = "Funding Information: This work was supported in part by NIH RO1 EB007920 and RO1 EB006433 and a grant from the Minnesota Partnership for Biotechnology and Medical Genomics . The authors thank Cindy Nelson for technical assistance in data collection, and Dr. Benjamin Brinkmann for assistance in data mining.",

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AU - Worrell, Gregory A.

AU - He, Bin

N1 - Funding Information: This work was supported in part by NIH RO1 EB007920 and RO1 EB006433 and a grant from the Minnesota Partnership for Biotechnology and Medical Genomics . The authors thank Cindy Nelson for technical assistance in data collection, and Dr. Benjamin Brinkmann for assistance in data mining.

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N2 - Objective: To investigate the usage of a high-density EEG recording system and source imaging technique for localizing seizure activity in patients with medically intractable partial epilepsy. Methods: High-density, 76-channel scalp EEG signals were recorded in 10 patients with partial epilepsy. The patients underwent routine clinical pre-surgical evaluation and all had resective surgery with seizure free outcome. After applying a FINE (first principle vectors) spatio-temporal source localization and DTF (directed transfer function) connectivity analysis approach, ictal sources were imaged. Effects of number of scalp EEG electrodes on the seizure localization were also assessed using 76, 64, 48, 32, and 21 electrodes, respectively. Results: Surgical resections were used to assess the source imaging results. Results from the 76-channel EEG in the 10 patients showed high correlation with the surgically resected brain regions. The localization of seizure onset zone from 76-channel EEG showed improved source detection accuracy compared to other EEG configurations with fewer electrodes. Conclusions: FINE together with DTF was able to localize seizure onset zones of partial epilepsy patients. High-density EEG recording can help achieve improved seizure source imaging. Significance: The present results suggest the promise of high-density EEG and electrical source imaging for noninvasively localizing seizure onset zones.

AB - Objective: To investigate the usage of a high-density EEG recording system and source imaging technique for localizing seizure activity in patients with medically intractable partial epilepsy. Methods: High-density, 76-channel scalp EEG signals were recorded in 10 patients with partial epilepsy. The patients underwent routine clinical pre-surgical evaluation and all had resective surgery with seizure free outcome. After applying a FINE (first principle vectors) spatio-temporal source localization and DTF (directed transfer function) connectivity analysis approach, ictal sources were imaged. Effects of number of scalp EEG electrodes on the seizure localization were also assessed using 76, 64, 48, 32, and 21 electrodes, respectively. Results: Surgical resections were used to assess the source imaging results. Results from the 76-channel EEG in the 10 patients showed high correlation with the surgically resected brain regions. The localization of seizure onset zone from 76-channel EEG showed improved source detection accuracy compared to other EEG configurations with fewer electrodes. Conclusions: FINE together with DTF was able to localize seizure onset zones of partial epilepsy patients. High-density EEG recording can help achieve improved seizure source imaging. Significance: The present results suggest the promise of high-density EEG and electrical source imaging for noninvasively localizing seizure onset zones.

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KW - High-density EEG

KW - Ictal activities

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Seizure source imaging by means of FINE spatio-temporal dipole localization and directed transfer function in partial epilepsy patients

Abstract

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