Segmental duplications contribute to gene expression differences between humans and chimpanzees

Ran Blekhman; Alicia Oshlack; Yoav Gilad

doi:10.1534/genetics.108.099960

Segmental duplications contribute to gene expression differences between humans and chimpanzees

Ran Blekhman, Alicia Oshlack, Yoav Gilad

Genetics, Cell Biology and Development (CBS)

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

In addition to specific changes in cis- and trans-regulatory elements, structural changes in the genome are hypothesized to underlie a large number of differences in gene expression between species. Accordingly, we show that species-specific segmental duplications are enriched with genes that are differentially expressed between humans and chimpanzees.

Original language	English (US)
Pages (from-to)	627-630
Number of pages	4
Journal	Genetics
Volume	182
Issue number	2
DOIs	https://doi.org/10.1534/genetics.108.099960
State	Published - Jun 2009

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title = "Segmental duplications contribute to gene expression differences between humans and chimpanzees",

abstract = "In addition to specific changes in cis- and trans-regulatory elements, structural changes in the genome are hypothesized to underlie a large number of differences in gene expression between species. Accordingly, we show that species-specific segmental duplications are enriched with genes that are differentially expressed between humans and chimpanzees.",

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Segmental duplications contribute to gene expression differences between humans and chimpanzees

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