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Seeking the Elusive Long-Acting Ozonide: Discovery of Artefenomel (OZ439)
Ho Shin Kim
, Jared T. Hammill
,
R. Kiplin Guy
Research output
:
Contribution to journal
›
Review article
›
peer-review
20
Scopus citations
Overview
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Keyphrases
Artemisinin-based Combination Therapy
100%
Ozonide
100%
OZ439
100%
Artefenomel
100%
Dosing Regimen
50%
Frontline Therapy
50%
Malaria
50%
Rapid Clearance
50%
Drug Combination
50%
Rapid Onset
50%
Prophylactic Activity
50%
Structure-activity Studies
50%
Extensive Structure
50%
Onset of Action
50%
Artemisinin
50%
Semi-synthetic Analogs
50%
Artemisinin Derivatives
50%
Improved Pharmacokinetics
50%
Cost of Goods
50%
Synthetic Ozonides
50%
Arterolane Maleate
50%
Pharmacology, Toxicology and Pharmaceutical Science
Ozonide
100%
Artemisinin
100%
Artefenomel
100%
Combination Therapy
66%
Arterolane
66%
Artemisinin Derivative
33%
Combination Drug
33%
Pharmacokinetics
33%
Biochemistry, Genetics and Molecular Biology
Single Drug Dose
100%
Pharmacokinetics
100%
Chemistry
Ozonide
100%
Pharmacokinetics
33%
Artemisinin Derivative
33%
Arterolane
33%