Sedimentary record of antibiotic accumulation in Minnesota Lakes

Jill F. Kerrigan, Kyle D. Sandberg, Daniel R. Engstrom, Timothy M LaPara, Bill Arnold

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The widespread detection of antibiotics in the environment is concerning because antibiotics are designed to be effective at small doses. The objective of this work was to quantify the accumulation rates of antibiotics used by humans and animals, spanning several major antibiotic classes (sulfonamides, tetracyclines, fluoroquinolones, and macrolides), in Minnesota lake-sediment cores. Our goal was to determine temporal trends, the major anthropogenic source to these lacustrine systems, and the importance of natural production. A historical record of usage trends for ten human and/or animal-use antibiotics (four sulfonamides, three fluoroquinolones, one macrolide, trimethoprim, and lincomycin) was faithfully captured in the sediment cores. Nine other antibiotics were not detected. Ofloxacin, trimethoprim, sulfapyridine, and sulfamethazine were detected in all of the anthropogenically-impacted studied lakes. Maximum sediment fluxes reached 20.5 ng cm− 2 yr− 1 (concentration 66.1 ng/g) for ofloxacin, 1.2 ng cm− 2 yr− 1 (1.2 ng/g) for trimethoprim, 3.3 ng cm− 2 yr− 1 (11.3 ng/g) for sulfapyridine, and 1.0 ng cm− 2 yr− 1 (1.6 ng/g) for sulfamethazine, respectively. Natural production of lincomycin may have occurred in one lake at fluxes ranging from 0.4 to 1.8 ng cm− 2 yr− 1 (0.1 to 5.8 ng/g). Wastewater effluent appears to be the primary source of antibiotics in the studied lakes, with lesser inputs from agricultural activities.

Original languageEnglish (US)
Pages (from-to)970-979
Number of pages10
JournalScience of the Total Environment
Volume621
DOIs
StatePublished - Apr 15 2018

Bibliographical note

Funding Information:
Thanks to the undergraduate researchers Robert Rudin III, Acadia Stephan, and Abby Kargol for their assistance with sediment extractions and Erin Mortenson of the St. Croix Watershed Research Station for the 210Pb analysis. Many thanks to Xun Ming and Peter Villalta at the University of Minnesota Cancer Center Mass Spectrometry Facility for their analytical support and the Limnological Research Center LacCore facility for assistance in core processing. This work was funded by the Minnesota Environmental and Natural Resources Trust fund (M.L. 2014, Chp. 226, Sec. 2, Subd. 03e) as recommended by the Legislative and Citizen Commission on Minnesota Resources and a Doctoral Dissertation Fellowship from the Graduate School at the University of Minnesota.

Funding Information:
Thanks to the undergraduate researchers Robert Rudin III, Acadia Stephan, and Abby Kargol for their assistance with sediment extractions and Erin Mortenson of the St. Croix Watershed Research Station for the 210 Pb analysis. Many thanks to Xun Ming and Peter Villalta at the University of Minnesota Cancer Center Mass Spectrometry Facility for their analytical support and the Limnological Research Center LacCore facility for assistance in core processing. This work was funded by the Minnesota Environmental and Natural Resources Trust fund (M.L. 2014, Chp. 226, Sec. 2, Subd. 03e) as recommended by the Legislative and Citizen Commission on Minnesota Resources and a Doctoral Dissertation Fellowship from the Graduate School at the University of Minnesota.

Publisher Copyright:
© 2017 Elsevier B.V.

Keywords

  • Antibiotics
  • Lakes
  • Sediment
  • Wastewater

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