Sedentary time and postmenopausal breast cancer incidence

Sarah J.O. Nomura; Chiranjeev Dash; Vanessa B. Sheppard; Deborah Bowen; Matthew Allison; Wendy Barrington; Rowan Chlebowski; Mace Coday; Lifang Hou; Barbara Howard; Michael LaMonte; Jo Ann E. Manson; Marian L. Neuhouser; Electra Paskett; Maryam Sattari; Marcia Stefanick; Jean Wactawski-Wende; Lucile L. Adams-Campbell

doi:10.1007/s10552-017-0968-x

Sedentary time and postmenopausal breast cancer incidence

Sarah J.O. Nomura, Chiranjeev Dash, Vanessa B. Sheppard, Deborah Bowen, Matthew Allison, Wendy Barrington, Rowan Chlebowski, Mace Coday, Lifang Hou, Barbara Howard, Michael LaMonte, Jo Ann E. Manson, Marian L. Neuhouser, Electra Paskett, Maryam Sattari, Marcia Stefanick, Jean Wactawski-Wende, Lucile L. Adams-Campbell

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Purpose: The objective of this study was to evaluate the prospective association between sedentary time and postmenopausal breast cancer incidence, and whether associations differ by race/ethnicity, physical activity levels, and body measurements. Methods: The Women’s Health Initiative Observational Study is a prospective cohort among women ages 50–79 years at baseline (1994–1998) (analytic cohort = 70,233). Baseline questionnaire data were used to estimate time spent sitting and total sedentary time. Associations between time spent sitting and invasive breast cancer incidence overall (n = 4,115 cases through September 2015), and by hormone receptor subtypes, were investigated using Cox proportional hazards regression. Analyses were replicated stratified by race/ethnicity, body measurements, and physical activity. Results: Among women in this study, 34.5% reported ≤ 5 h/day sitting, 40.9% reported 6–9 h/day and 24.7% reported ≥ 10 h/day. Time spent sitting (≥ 10 vs. ≤5 h/day adjusted HR = 1.00, 95% CI 0.92–1.09) was not associated with breast cancer incidence, regardless of hormone receptor subtype. Associations did not differ by race/ethnicity, physical activity, or body measurements. Conclusions: Results from this study do not support an association between sedentary time and breast cancer incidence.

Original language	English (US)
Pages (from-to)	1405-1416
Number of pages	12
Journal	Cancer Causes and Control
Volume	28
Issue number	12
DOIs	https://doi.org/10.1007/s10552-017-0968-x
State	Published - Dec 1 2017
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgments The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through contracts HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, and HHSN268201600004C. The authors would like to acknowledge the WHI Program Office, including (National Heart, Lung, and Blood Institute, Bethesda Maryland), Jacques Rossouw, Shari Ludlam, Joan McGowan, Leslie Ford, and Nancy Geller, Clinical Coordinating Center: (Fred Hutchinson Cancer Research Center, Seattle, WA) Garnet Anderson, Ross Prentice, Andrea LaCroix, and Charles Kooperberg; Investigators and Academic Centers including (Brigham and Women’s Hospital, Harvard Medical School, Boston, MA) JoAnn E. Manson; (MedStar Health Research Institute/Howard University, Washington, DC) Barbara V. Howard; (Stanford Prevention Research Center, Stanford, CA) Marcia L. Stefanick; (The Ohio State University, Columbus, OH) Rebecca Jackson; (University of Arizona, Tucson/Phoenix, AZ) Cynthia A. Thomson; (University at Buffalo, Buffalo, NY) Jean Wactawski-Wende; (University of Florida, Gainesville/Jacksonville, FL) Marian Limacher; (University of Iowa, Iowa City/Davenport, IA) Jennifer Robinson; (University of Pittsburgh, Pittsburgh, PA) Lewis Kuller; (Wake Forest University School of Medicine, Winston-Salem, NC) Sally Shumaker; (University of Nevada, Reno, NV) Robert Brun-ner; (University of Minnesota, Minneapolis, MN) Karen L. Margolis; And Women’s Health Initiative Memory Study (Wake Forest University School of Medicine, Winston-Salem, NC) Mark Espeland.

Publisher Copyright:
© 2017, Springer International Publishing AG.

Keywords

Body composition
Breast cancer
Physical activity
Sedentary
Sitting time

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10552-017-0968-x

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687985

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Nomura, S. J. O., Dash, C., Sheppard, V. B., Bowen, D., Allison, M., Barrington, W., Chlebowski, R., Coday, M., Hou, L., Howard, B., LaMonte, M., Manson, J. A. E., Neuhouser, M. L., Paskett, E., Sattari, M., Stefanick, M., Wactawski-Wende, J., & Adams-Campbell, L. L. (2017). Sedentary time and postmenopausal breast cancer incidence. Cancer Causes and Control, 28(12), 1405-1416. https://doi.org/10.1007/s10552-017-0968-x

Nomura, SJO, Dash, C, Sheppard, VB, Bowen, D, Allison, M, Barrington, W, Chlebowski, R, Coday, M, Hou, L, Howard, B, LaMonte, M, Manson, JAE, Neuhouser, ML, Paskett, E, Sattari, M, Stefanick, M, Wactawski-Wende, J & Adams-Campbell, LL 2017, 'Sedentary time and postmenopausal breast cancer incidence', Cancer Causes and Control, vol. 28, no. 12, pp. 1405-1416. https://doi.org/10.1007/s10552-017-0968-x

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abstract = "Purpose: The objective of this study was to evaluate the prospective association between sedentary time and postmenopausal breast cancer incidence, and whether associations differ by race/ethnicity, physical activity levels, and body measurements. Methods: The Women{\textquoteright}s Health Initiative Observational Study is a prospective cohort among women ages 50–79 years at baseline (1994–1998) (analytic cohort = 70,233). Baseline questionnaire data were used to estimate time spent sitting and total sedentary time. Associations between time spent sitting and invasive breast cancer incidence overall (n = 4,115 cases through September 2015), and by hormone receptor subtypes, were investigated using Cox proportional hazards regression. Analyses were replicated stratified by race/ethnicity, body measurements, and physical activity. Results: Among women in this study, 34.5% reported ≤ 5 h/day sitting, 40.9% reported 6–9 h/day and 24.7% reported ≥ 10 h/day. Time spent sitting (≥ 10 vs. ≤5 h/day adjusted HR = 1.00, 95% CI 0.92–1.09) was not associated with breast cancer incidence, regardless of hormone receptor subtype. Associations did not differ by race/ethnicity, physical activity, or body measurements. Conclusions: Results from this study do not support an association between sedentary time and breast cancer incidence.",

keywords = "Body composition, Breast cancer, Physical activity, Sedentary, Sitting time",

author = "Nomura, {Sarah J.O.} and Chiranjeev Dash and Sheppard, {Vanessa B.} and Deborah Bowen and Matthew Allison and Wendy Barrington and Rowan Chlebowski and Mace Coday and Lifang Hou and Barbara Howard and Michael LaMonte and Manson, {Jo Ann E.} and Neuhouser, {Marian L.} and Electra Paskett and Maryam Sattari and Marcia Stefanick and Jean Wactawski-Wende and Adams-Campbell, {Lucile L.}",

note = "Funding Information: Acknowledgments The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through contracts HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, and HHSN268201600004C. The authors would like to acknowledge the WHI Program Office, including (National Heart, Lung, and Blood Institute, Bethesda Maryland), Jacques Rossouw, Shari Ludlam, Joan McGowan, Leslie Ford, and Nancy Geller, Clinical Coordinating Center: (Fred Hutchinson Cancer Research Center, Seattle, WA) Garnet Anderson, Ross Prentice, Andrea LaCroix, and Charles Kooperberg; Investigators and Academic Centers including (Brigham and Women{\textquoteright}s Hospital, Harvard Medical School, Boston, MA) JoAnn E. Manson; (MedStar Health Research Institute/Howard University, Washington, DC) Barbara V. Howard; (Stanford Prevention Research Center, Stanford, CA) Marcia L. Stefanick; (The Ohio State University, Columbus, OH) Rebecca Jackson; (University of Arizona, Tucson/Phoenix, AZ) Cynthia A. Thomson; (University at Buffalo, Buffalo, NY) Jean Wactawski-Wende; (University of Florida, Gainesville/Jacksonville, FL) Marian Limacher; (University of Iowa, Iowa City/Davenport, IA) Jennifer Robinson; (University of Pittsburgh, Pittsburgh, PA) Lewis Kuller; (Wake Forest University School of Medicine, Winston-Salem, NC) Sally Shumaker; (University of Nevada, Reno, NV) Robert Brun-ner; (University of Minnesota, Minneapolis, MN) Karen L. Margolis; And Women{\textquoteright}s Health Initiative Memory Study (Wake Forest University School of Medicine, Winston-Salem, NC) Mark Espeland. Publisher Copyright: {\textcopyright} 2017, Springer International Publishing AG.",

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T1 - Sedentary time and postmenopausal breast cancer incidence

AU - Nomura, Sarah J.O.

AU - Dash, Chiranjeev

AU - Sheppard, Vanessa B.

AU - Bowen, Deborah

AU - Allison, Matthew

AU - Barrington, Wendy

AU - Chlebowski, Rowan

AU - Coday, Mace

AU - Hou, Lifang

AU - Howard, Barbara

AU - LaMonte, Michael

AU - Manson, Jo Ann E.

AU - Neuhouser, Marian L.

AU - Paskett, Electra

AU - Sattari, Maryam

AU - Stefanick, Marcia

AU - Wactawski-Wende, Jean

AU - Adams-Campbell, Lucile L.

N1 - Funding Information: Acknowledgments The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through contracts HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, and HHSN268201600004C. The authors would like to acknowledge the WHI Program Office, including (National Heart, Lung, and Blood Institute, Bethesda Maryland), Jacques Rossouw, Shari Ludlam, Joan McGowan, Leslie Ford, and Nancy Geller, Clinical Coordinating Center: (Fred Hutchinson Cancer Research Center, Seattle, WA) Garnet Anderson, Ross Prentice, Andrea LaCroix, and Charles Kooperberg; Investigators and Academic Centers including (Brigham and Women’s Hospital, Harvard Medical School, Boston, MA) JoAnn E. Manson; (MedStar Health Research Institute/Howard University, Washington, DC) Barbara V. Howard; (Stanford Prevention Research Center, Stanford, CA) Marcia L. Stefanick; (The Ohio State University, Columbus, OH) Rebecca Jackson; (University of Arizona, Tucson/Phoenix, AZ) Cynthia A. Thomson; (University at Buffalo, Buffalo, NY) Jean Wactawski-Wende; (University of Florida, Gainesville/Jacksonville, FL) Marian Limacher; (University of Iowa, Iowa City/Davenport, IA) Jennifer Robinson; (University of Pittsburgh, Pittsburgh, PA) Lewis Kuller; (Wake Forest University School of Medicine, Winston-Salem, NC) Sally Shumaker; (University of Nevada, Reno, NV) Robert Brun-ner; (University of Minnesota, Minneapolis, MN) Karen L. Margolis; And Women’s Health Initiative Memory Study (Wake Forest University School of Medicine, Winston-Salem, NC) Mark Espeland. Publisher Copyright: © 2017, Springer International Publishing AG.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Purpose: The objective of this study was to evaluate the prospective association between sedentary time and postmenopausal breast cancer incidence, and whether associations differ by race/ethnicity, physical activity levels, and body measurements. Methods: The Women’s Health Initiative Observational Study is a prospective cohort among women ages 50–79 years at baseline (1994–1998) (analytic cohort = 70,233). Baseline questionnaire data were used to estimate time spent sitting and total sedentary time. Associations between time spent sitting and invasive breast cancer incidence overall (n = 4,115 cases through September 2015), and by hormone receptor subtypes, were investigated using Cox proportional hazards regression. Analyses were replicated stratified by race/ethnicity, body measurements, and physical activity. Results: Among women in this study, 34.5% reported ≤ 5 h/day sitting, 40.9% reported 6–9 h/day and 24.7% reported ≥ 10 h/day. Time spent sitting (≥ 10 vs. ≤5 h/day adjusted HR = 1.00, 95% CI 0.92–1.09) was not associated with breast cancer incidence, regardless of hormone receptor subtype. Associations did not differ by race/ethnicity, physical activity, or body measurements. Conclusions: Results from this study do not support an association between sedentary time and breast cancer incidence.

AB - Purpose: The objective of this study was to evaluate the prospective association between sedentary time and postmenopausal breast cancer incidence, and whether associations differ by race/ethnicity, physical activity levels, and body measurements. Methods: The Women’s Health Initiative Observational Study is a prospective cohort among women ages 50–79 years at baseline (1994–1998) (analytic cohort = 70,233). Baseline questionnaire data were used to estimate time spent sitting and total sedentary time. Associations between time spent sitting and invasive breast cancer incidence overall (n = 4,115 cases through September 2015), and by hormone receptor subtypes, were investigated using Cox proportional hazards regression. Analyses were replicated stratified by race/ethnicity, body measurements, and physical activity. Results: Among women in this study, 34.5% reported ≤ 5 h/day sitting, 40.9% reported 6–9 h/day and 24.7% reported ≥ 10 h/day. Time spent sitting (≥ 10 vs. ≤5 h/day adjusted HR = 1.00, 95% CI 0.92–1.09) was not associated with breast cancer incidence, regardless of hormone receptor subtype. Associations did not differ by race/ethnicity, physical activity, or body measurements. Conclusions: Results from this study do not support an association between sedentary time and breast cancer incidence.

KW - Body composition

KW - Breast cancer

KW - Physical activity

KW - Sedentary

KW - Sitting time

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Sedentary time and postmenopausal breast cancer incidence

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

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