Secondary malignant giant-cell tumor of bone. Clinicopathological assessment of nineteen patients

M. G. Rock, F. H. Sim, K. K. Unni, Geoffrey A Witrak, F. J. Frassica, M. F. Schray, J. W. Beabout, D. C. Dahlin

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Abstract

Twenty-six patients who had a malignant giant-cell tumor of bone - a sarcoma either juxtaposed to a zone of typical benign giant-cell tumor or occurring at the site of a previously documented benign giant-cell tumor - have been seen at the Mayo Clinic. Of the twenty-six tumors, nineteen were secondary to a previous attempt at local control of a benign giant-cell tumor. All but one of these nineteen patients with a secondary tumor had received therapeutic irradiation four to thirty-nine years earlier. The nature and duration of the symptoms and the sites of predilection of the malignant giant-cell tumors were the same as for benign giant-cell tumor. Fibrosarcoma occurred three times as frequently as osteosarcoma. The best results of treatment of the secondary sarcoma were obtained with early ablation.

Original languageEnglish (US)
Pages (from-to)1073-1079
Number of pages7
JournalJournal of Bone and Joint Surgery - Series A
Volume68
Issue number7
DOIs
StatePublished - Jan 1 1986

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Rock, M. G., Sim, F. H., Unni, K. K., Witrak, G. A., Frassica, F. J., Schray, M. F., Beabout, J. W., & Dahlin, D. C. (1986). Secondary malignant giant-cell tumor of bone. Clinicopathological assessment of nineteen patients. Journal of Bone and Joint Surgery - Series A, 68(7), 1073-1079. https://doi.org/10.2106/00004623-198668070-00016