Secondary hyperparathyroidism: Pathophysiology and treatment

Wissam Saliba, Boutros El-Haddad

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations


Secondary hyperparathyroidism is a frequently encountered problem in the management of patients with chronic kidney disease (CKD). Its pathophysiology is mainly due to hyperphosphatemia and vitamin D deficiency and resistance. This condition has a high impact on the mortality and morbidity of dialysis patients. Early diagnosis of secondary hyperparathyroidism is crucial in the management of patients with CKD. The treatment remains a challenge for patients and their clinicians. It should include a combination of dietary phosphorus restriction, phosphate binders, vitamin D analogues, and calcimimetics.

Original languageEnglish (US)
Pages (from-to)574-581
Number of pages8
JournalJournal of the American Board of Family Medicine
Issue number5
StatePublished - Sep 2009


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