Secondary Hormonal Manipulations in Prostate Cancer

Charles J. Ryan

doi:10.1016/j.hoc.2006.03.005

Secondary Hormonal Manipulations in Prostate Cancer

Charles J. Ryan

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Targeting AIPC with therapies that affect the mechanisms of androgen receptor signaling despite a castrate testosterone milieu is an active and growing area of clinical research. At present, for patients with AIPC, the data support the maintenance of the castrate state, recognition of the AAWD phenomenon, the sequential use of oral antiandrogens, and a trial of estrogens or adrenal androgen-targeted therapies. Novel agents are being developed that seek to prolong the duration of clinical responses and the overall response rate.

Original language	English (US)
Pages (from-to)	925-934
Number of pages	10
Journal	Hematology/Oncology Clinics of North America
Volume	20
Issue number	4
DOIs	https://doi.org/10.1016/j.hoc.2006.03.005
State	Published - Aug 1 2006
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.hoc.2006.03.005

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title = "Secondary Hormonal Manipulations in Prostate Cancer",

abstract = "Targeting AIPC with therapies that affect the mechanisms of androgen receptor signaling despite a castrate testosterone milieu is an active and growing area of clinical research. At present, for patients with AIPC, the data support the maintenance of the castrate state, recognition of the AAWD phenomenon, the sequential use of oral antiandrogens, and a trial of estrogens or adrenal androgen-targeted therapies. Novel agents are being developed that seek to prolong the duration of clinical responses and the overall response rate.",

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year = "2006",

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doi = "10.1016/j.hoc.2006.03.005",

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publisher = "W.B. Saunders",

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AU - Ryan, Charles J.

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AB - Targeting AIPC with therapies that affect the mechanisms of androgen receptor signaling despite a castrate testosterone milieu is an active and growing area of clinical research. At present, for patients with AIPC, the data support the maintenance of the castrate state, recognition of the AAWD phenomenon, the sequential use of oral antiandrogens, and a trial of estrogens or adrenal androgen-targeted therapies. Novel agents are being developed that seek to prolong the duration of clinical responses and the overall response rate.

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U2 - 10.1016/j.hoc.2006.03.005

DO - 10.1016/j.hoc.2006.03.005

M3 - Review article

C2 - 16861123

AN - SCOPUS:33746210089

SN - 0889-8588

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SP - 925

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JO - Hematology/Oncology Clinics of North America

JF - Hematology/Oncology Clinics of North America

IS - 4

ER -

Secondary Hormonal Manipulations in Prostate Cancer

Abstract

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