Seasonal variation in penicillin susceptibility and invasive pneumococcal disease

Pui Ying Iroh Tam, Lawrence C. Madoff, Michael O'Connell, Stephen I. Pelton

Research output: Contribution to journalShort surveypeer-review

6 Scopus citations


We evaluated prospectively laboratory surveillance data from Massachusetts to investigate whether seasonal variation in invasive pneumococcal disease is associated with the proportion of penicillin-susceptible isolates. The proportion of penicillin-susceptible isolates associated with invasive pneumococcal disease varied by season, with proportions highest in the winter and lowest in the summer, and rates of invasive disease were highest in the autumn and winter seasons and lowest in the summer.

Original languageEnglish (US)
Pages (from-to)456-457
Number of pages2
JournalPediatric Infectious Disease Journal
Issue number4
StatePublished - Apr 21 2015

Bibliographical note

Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc.


  • clinical outcome
  • invasive pneumococcal disease
  • pediatric
  • penicillin susceptibility
  • seasonality


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