Sea-blue histiocyte and posterior column dysfunction: A familial disorder

Kenneth F Swaiman, Bhuwan P. Garg, Lawrence A. Lockman

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

This is a report of a new familial neurologic disorder characterized by ceroid-lipofuscin storage, sea-blue histiocytes, and associated neurologic findings. Neurologic manifestations in the family members examined were varied, but posterior column involvement was the most common finding. The presence of sea-blue histiocytes was genetically determined by an autosomal dominant trait. Vitamin E blood concentrations were decreased in the absence of absorption difficulties in two sisters who were most seriously affected. The relationship of ceroid-lipofuscin, lipid peroxidation, and vitamin E is discussed.

Original languageEnglish (US)
Pages (from-to)1084-1087
Number of pages4
JournalNeurology
Volume25
Issue number11
DOIs
StatePublished - Nov 1975

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