Scope and limitation of propylene carbonate as a sustainable solvent in the Suzuki-Miyaura reaction

Andrea Czompa, Balázs László Pásztor, Jennifer Alizadeh Sahar, Zoltán Mucsi, Dóra Bogdán, Krisztina Ludányi, Zoltán Varga, István M. Mándity

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2 Scopus citations

Abstract

The Suzuki-Miyaura reaction is one of the most used transformations in drug research. Thus making this reaction more sustainable is of considerable current interest. Here we show that propylene carbonate (PC) can be used as a solvent for the Suzuki-Miyaura reaction. PC is one of the greenest solvents since it is synthesized under green conditions by the use of carbon dioxide in the air. All reactions proceeded well and good or excellent yields were observed for the biaryl products. Nonetheless in the case of pyridazinones, 2-hydroxypropyl- chain containing side-products were observed. Importantly, this fact allowed the isolation of several novel compounds which were generated under prominently green conditions.

Original languageEnglish (US)
Pages (from-to)37818-37824
Number of pages7
JournalRSC Advances
Volume9
Issue number65
DOIs
StatePublished - 2019
Externally publishedYes

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    Czompa, A., Pásztor, B. L., Sahar, J. A., Mucsi, Z., Bogdán, D., Ludányi, K., Varga, Z., & Mándity, I. M. (2019). Scope and limitation of propylene carbonate as a sustainable solvent in the Suzuki-Miyaura reaction. RSC Advances, 9(65), 37818-37824. https://doi.org/10.1039/c9ra07044c