Scope and limitation of propylene carbonate as a sustainable solvent in the Suzuki-Miyaura reaction

Andrea Czompa; Balázs László Pásztor; Jennifer Alizadeh Sahar; Zoltán Mucsi; Dóra Bogdán; Krisztina Ludányi; Zoltán Varga; István M. Mándity

doi:10.1039/c9ra07044c

Scope and limitation of propylene carbonate as a sustainable solvent in the Suzuki-Miyaura reaction

Andrea Czompa, Balázs László Pásztor, Jennifer Alizadeh Sahar, Zoltán Mucsi, Dóra Bogdán, Krisztina Ludányi, Zoltán Varga, István M. Mándity

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The Suzuki-Miyaura reaction is one of the most used transformations in drug research. Thus making this reaction more sustainable is of considerable current interest. Here we show that propylene carbonate (PC) can be used as a solvent for the Suzuki-Miyaura reaction. PC is one of the greenest solvents since it is synthesized under green conditions by the use of carbon dioxide in the air. All reactions proceeded well and good or excellent yields were observed for the biaryl products. Nonetheless in the case of pyridazinones, 2-hydroxypropyl- chain containing side-products were observed. Importantly, this fact allowed the isolation of several novel compounds which were generated under prominently green conditions.

Original language	English (US)
Pages (from-to)	37818-37824
Number of pages	7
Journal	RSC Advances
Volume	9
Issue number	65
DOIs	https://doi.org/10.1039/c9ra07044c
State	Published - 2019
Externally published	Yes

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© 2019 The Royal Society of Chemistry.

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abstract = "The Suzuki-Miyaura reaction is one of the most used transformations in drug research. Thus making this reaction more sustainable is of considerable current interest. Here we show that propylene carbonate (PC) can be used as a solvent for the Suzuki-Miyaura reaction. PC is one of the greenest solvents since it is synthesized under green conditions by the use of carbon dioxide in the air. All reactions proceeded well and good or excellent yields were observed for the biaryl products. Nonetheless in the case of pyridazinones, 2-hydroxypropyl- chain containing side-products were observed. Importantly, this fact allowed the isolation of several novel compounds which were generated under prominently green conditions.",

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AU - Czompa, Andrea

AU - Pásztor, Balázs László

AU - Sahar, Jennifer Alizadeh

AU - Mucsi, Zoltán

AU - Bogdán, Dóra

AU - Ludányi, Krisztina

AU - Varga, Zoltán

AU - Mándity, István M.

PY - 2019

Y1 - 2019

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AB - The Suzuki-Miyaura reaction is one of the most used transformations in drug research. Thus making this reaction more sustainable is of considerable current interest. Here we show that propylene carbonate (PC) can be used as a solvent for the Suzuki-Miyaura reaction. PC is one of the greenest solvents since it is synthesized under green conditions by the use of carbon dioxide in the air. All reactions proceeded well and good or excellent yields were observed for the biaryl products. Nonetheless in the case of pyridazinones, 2-hydroxypropyl- chain containing side-products were observed. Importantly, this fact allowed the isolation of several novel compounds which were generated under prominently green conditions.

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Scope and limitation of propylene carbonate as a sustainable solvent in the Suzuki-Miyaura reaction

Abstract

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