Sclerouveitis with exudative retinal detachment associated with chronic myelomonocytic leukemia

Kristine M. Nachbor; Caroline L. Minkus

doi:10.1016/j.ajoc.2022.101573

Sclerouveitis with exudative retinal detachment associated with chronic myelomonocytic leukemia

Kristine M. Nachbor
, Caroline L. Minkus

Ophthalmology & Visual Neurosciences

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Purpose: To describe a case of sclerouveitis with exudative retinal detachment in a patient with chronic myelomonocytic leukemia. Observations: An 82-year-old woman with chronic myelomonocytic leukemia (CMML) presented with acute painful right eye redness and decreased visual acuity. Examination revealed right eye anterior and posterior scleritis with exudative retinal detachment, as well as 2+ anterior chamber cell in the right eye and 0.5+ in the left eye. Workup was negative for infectious etiologies and chest imaging revealed no pulmonary nodules. She was treated with prednisolone drops and a tapering course of oral prednisone as she started therapy with ruxolitinib for CMML. Inflammation resolved with treatment, and she remained quiet off steroids while on ruxolitinib. Conclusions and importance: This is the first case report to specifically describe sclerouveitis associated with CMML, despite the known association of this cancer with various inflammatory manifestations. This case demonstrates that CMML may present with scleritis and uveitis, and should be considered as the underlying etiology of inflammatory eye disease in patients with a diagnosis of CMML.

Original language	English (US)
Article number	101573
Journal	American Journal of Ophthalmology Case Reports
Volume	26
DOIs	https://doi.org/10.1016/j.ajoc.2022.101573
State	Published - Jun 2022

Bibliographical note

Funding Information:
No funding or grant support. The following authors have no financial disclosures: KMN, CLM. All authors attest that they meet the current ICMJE criteria for Authorship. No acknowledgements.

Publisher Copyright:
© 2022 The Authors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chronic myelomonocytic leukemia
Eye inflammation
Masquerade
Scleritis
Uveitis

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title = "Sclerouveitis with exudative retinal detachment associated with chronic myelomonocytic leukemia",

abstract = "Purpose: To describe a case of sclerouveitis with exudative retinal detachment in a patient with chronic myelomonocytic leukemia. Observations: An 82-year-old woman with chronic myelomonocytic leukemia (CMML) presented with acute painful right eye redness and decreased visual acuity. Examination revealed right eye anterior and posterior scleritis with exudative retinal detachment, as well as 2+ anterior chamber cell in the right eye and 0.5+ in the left eye. Workup was negative for infectious etiologies and chest imaging revealed no pulmonary nodules. She was treated with prednisolone drops and a tapering course of oral prednisone as she started therapy with ruxolitinib for CMML. Inflammation resolved with treatment, and she remained quiet off steroids while on ruxolitinib. Conclusions and importance: This is the first case report to specifically describe sclerouveitis associated with CMML, despite the known association of this cancer with various inflammatory manifestations. This case demonstrates that CMML may present with scleritis and uveitis, and should be considered as the underlying etiology of inflammatory eye disease in patients with a diagnosis of CMML.",

keywords = "Chronic myelomonocytic leukemia, Eye inflammation, Masquerade, Scleritis, Uveitis",

author = "Nachbor, \{Kristine M.\} and Minkus, \{Caroline L.\}",

note = "Funding Information: No funding or grant support. The following authors have no financial disclosures: KMN, CLM. All authors attest that they meet the current ICMJE criteria for Authorship. No acknowledgements. Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = jun,

doi = "10.1016/j.ajoc.2022.101573",

language = "English (US)",

volume = "26",

journal = "American Journal of Ophthalmology Case Reports",

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AU - Nachbor, Kristine M.

AU - Minkus, Caroline L.

N1 - Funding Information: No funding or grant support. The following authors have no financial disclosures: KMN, CLM. All authors attest that they meet the current ICMJE criteria for Authorship. No acknowledgements. Publisher Copyright: © 2022 The Authors

PY - 2022/6

Y1 - 2022/6

N2 - Purpose: To describe a case of sclerouveitis with exudative retinal detachment in a patient with chronic myelomonocytic leukemia. Observations: An 82-year-old woman with chronic myelomonocytic leukemia (CMML) presented with acute painful right eye redness and decreased visual acuity. Examination revealed right eye anterior and posterior scleritis with exudative retinal detachment, as well as 2+ anterior chamber cell in the right eye and 0.5+ in the left eye. Workup was negative for infectious etiologies and chest imaging revealed no pulmonary nodules. She was treated with prednisolone drops and a tapering course of oral prednisone as she started therapy with ruxolitinib for CMML. Inflammation resolved with treatment, and she remained quiet off steroids while on ruxolitinib. Conclusions and importance: This is the first case report to specifically describe sclerouveitis associated with CMML, despite the known association of this cancer with various inflammatory manifestations. This case demonstrates that CMML may present with scleritis and uveitis, and should be considered as the underlying etiology of inflammatory eye disease in patients with a diagnosis of CMML.

AB - Purpose: To describe a case of sclerouveitis with exudative retinal detachment in a patient with chronic myelomonocytic leukemia. Observations: An 82-year-old woman with chronic myelomonocytic leukemia (CMML) presented with acute painful right eye redness and decreased visual acuity. Examination revealed right eye anterior and posterior scleritis with exudative retinal detachment, as well as 2+ anterior chamber cell in the right eye and 0.5+ in the left eye. Workup was negative for infectious etiologies and chest imaging revealed no pulmonary nodules. She was treated with prednisolone drops and a tapering course of oral prednisone as she started therapy with ruxolitinib for CMML. Inflammation resolved with treatment, and she remained quiet off steroids while on ruxolitinib. Conclusions and importance: This is the first case report to specifically describe sclerouveitis associated with CMML, despite the known association of this cancer with various inflammatory manifestations. This case demonstrates that CMML may present with scleritis and uveitis, and should be considered as the underlying etiology of inflammatory eye disease in patients with a diagnosis of CMML.

KW - Chronic myelomonocytic leukemia

KW - Eye inflammation

KW - Masquerade

KW - Scleritis

KW - Uveitis

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Sclerouveitis with exudative retinal detachment associated with chronic myelomonocytic leukemia

Abstract

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