An efficient route to N-acyl taxol analogues is described utilizing N-debenzoyltaxol (11). Acylation of 11 with various acid chlorides under Schotten-Baumann conditions led to a facile one step synthesis of several N-acyl taxol analogues from a common intermediate.
|Original language||English (US)|
|Number of pages||4|
|Journal||Bioorganic and Medicinal Chemistry Letters|
|State||Published - Jan 20 1994|