Schotten-Baumann acylation of N-debenzoyltaxol; an efficient route to N-acyl taxol analogues and their biological evaluation

Gunda I. Georg; Thomas C. Boge; Zacharia S. Cheruvallath; Geraldine C.B. Harriman; Michael Hepperle; Haeil Park; Richard H. Himes

doi:10.1016/S0960-894X(01)80139-6

Schotten-Baumann acylation of N-debenzoyltaxol; an efficient route to N-acyl taxol analogues and their biological evaluation

Gunda I. Georg, Thomas C. Boge, Zacharia S. Cheruvallath, Geraldine C.B. Harriman, Michael Hepperle, Haeil Park, Richard H. Himes

Medicinal Chemistry

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Abstract

An efficient route to N-acyl taxol analogues is described utilizing N-debenzoyltaxol (11). Acylation of 11 with various acid chlorides under Schotten-Baumann conditions led to a facile one step synthesis of several N-acyl taxol analogues from a common intermediate.

Original language	English (US)
Pages (from-to)	335-338
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/S0960-894X(01)80139-6
State	Published - Jan 20 1994

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title = "Schotten-Baumann acylation of N-debenzoyltaxol; an efficient route to N-acyl taxol analogues and their biological evaluation",

abstract = "An efficient route to N-acyl taxol analogues is described utilizing N-debenzoyltaxol (11). Acylation of 11 with various acid chlorides under Schotten-Baumann conditions led to a facile one step synthesis of several N-acyl taxol analogues from a common intermediate.",

author = "Georg, {Gunda I.} and Boge, {Thomas C.} and Cheruvallath, {Zacharia S.} and Harriman, {Geraldine C.B.} and Michael Hepperle and Haeil Park and Himes, {Richard H.}",

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T1 - Schotten-Baumann acylation of N-debenzoyltaxol; an efficient route to N-acyl taxol analogues and their biological evaluation

AU - Georg, Gunda I.

AU - Boge, Thomas C.

AU - Cheruvallath, Zacharia S.

AU - Harriman, Geraldine C.B.

AU - Hepperle, Michael

AU - Park, Haeil

AU - Himes, Richard H.

PY - 1994/1/20

Y1 - 1994/1/20

N2 - An efficient route to N-acyl taxol analogues is described utilizing N-debenzoyltaxol (11). Acylation of 11 with various acid chlorides under Schotten-Baumann conditions led to a facile one step synthesis of several N-acyl taxol analogues from a common intermediate.

AB - An efficient route to N-acyl taxol analogues is described utilizing N-debenzoyltaxol (11). Acylation of 11 with various acid chlorides under Schotten-Baumann conditions led to a facile one step synthesis of several N-acyl taxol analogues from a common intermediate.

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ER -

Schotten-Baumann acylation of N-debenzoyltaxol; an efficient route to N-acyl taxol analogues and their biological evaluation

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