Schotten-Baumann acylation of N-debenzoyltaxol; an efficient route to N-acyl taxol analogues and their biological evaluation

Gunda I. Georg, Thomas C. Boge, Zacharia S. Cheruvallath, Geraldine C.B. Harriman, Michael Hepperle, Haeil Park, Richard H. Himes

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

An efficient route to N-acyl taxol analogues is described utilizing N-debenzoyltaxol (11). Acylation of 11 with various acid chlorides under Schotten-Baumann conditions led to a facile one step synthesis of several N-acyl taxol analogues from a common intermediate.

Original languageEnglish (US)
Pages (from-to)335-338
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number2
DOIs
StatePublished - Jan 20 1994

Fingerprint Dive into the research topics of 'Schotten-Baumann acylation of N-debenzoyltaxol; an efficient route to N-acyl taxol analogues and their biological evaluation'. Together they form a unique fingerprint.

Cite this