Schizophrenia genetics at the millennium: Cautious optimism

Irving I. Gottesman, Steven O. Moldin

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


As the new millennium approaches, research into the genetic aspects of schizophrenia has already made an impressive start toward an integrated model which is discovering roles for genetic agents, environmental agents and experiences, and chance factors. The best model follows that proposed for understanding such complex diseases as coronary artery disease and diabetes. Genetic information has come from both genetic epidemiology and molecular genetics. Evidence for gene regions on 6p and 8p gives the strongest support for harboring schizophrenia susceptibility genes, based on international collaborative studies that 'generally' replicate one another; evidence for regions on 3p, 5q, 9p, 20p, and 22q, while less compelling, will encourage focused work. Determining the steps between the regions and the phenotype will challenge the next generation of scientists.

Original languageEnglish (US)
Pages (from-to)404-407
Number of pages4
JournalClinical Genetics
Issue number5
StatePublished - Nov 1997
Externally publishedYes


  • Epigenetic
  • Linkage
  • Multifactorial disease
  • QTL
  • Susceptibility genes


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