Schizophrenia classification with single-trial MEG during language processing

Tingting Xu, Massoud Stephane, Keshab K. Parhi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Language disorder is a core symptom associated with schizophrenia. This study investigates schizophrenia classification based on brain activity during language processing. 6 healthy controls and 6 schizophrenia patients were instructed to read words and sentences silently while 248 channel magnetoencephalography (MEG) signals were recorded. For each trial, power spectral features were extracted in 8 frequency bands from all channels which form a spectral-spatial feature set. Top features ranked by F-score were fed into machine learning based classifiers for patient and control classification. Following cross validation procedure, 98.94% and 99.78% accuracies were achieved in classifying 470 word trials and 450 sentence trials, respectively. The high accuracy indicates abnormalities of brain activity during language processing in patient group and show that MEG patterns reflecting such abnormalities can be used to discriminate schizophrenia patients from healthy subjects. The proposed scheme may have potential application in schizophrenia diagnosis and classifying other mental diseases.

Original languageEnglish (US)
Title of host publicationConference Record of the 47th Asilomar Conference on Signals, Systems and Computers
PublisherIEEE Computer Society
Pages354-357
Number of pages4
ISBN (Print)9781479923908
DOIs
StatePublished - Jan 1 2013
Event2013 47th Asilomar Conference on Signals, Systems and Computers - Pacific Grove, CA, United States
Duration: Nov 3 2013Nov 6 2013

Publication series

NameConference Record - Asilomar Conference on Signals, Systems and Computers
ISSN (Print)1058-6393

Other

Other2013 47th Asilomar Conference on Signals, Systems and Computers
CountryUnited States
CityPacific Grove, CA
Period11/3/1311/6/13

Keywords

  • classification
  • language processing
  • magnetoencephalography (MEG)
  • schizophrenia

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  • Cite this

    Xu, T., Stephane, M., & Parhi, K. K. (2013). Schizophrenia classification with single-trial MEG during language processing. In Conference Record of the 47th Asilomar Conference on Signals, Systems and Computers (pp. 354-357). [6810294] (Conference Record - Asilomar Conference on Signals, Systems and Computers). IEEE Computer Society. https://doi.org/10.1109/ACSSC.2013.6810294