Schizophrenia: A neurodevelopmental perspective

Heather M. Conklin, William G Iacono

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Diverse lines of research suggest that schizophrenia is a genetically influenced neurodevelopmental disorder. Family, twin, and adoption studies suggest that most cases of schizophrenia involve a genetic diathesis that is necessary but not sufficient for development of the disorder. Histological, neuroimaging, and neuropsychological findings converge in providing evidence for medialtemporal and frontal lobe dysfunction that likely predates the onset of psychosis. Behavioral phenomenology and neurobiology suggest that dopamine plays a crucial moderating role between these structural abnormalities and functional impairment. Recently, investigators have used animal models and clinical syndromes to integrate these findings into neurodevelopmental models of schizophrenia that hold great potential for yielding etiological insight.

Original languageEnglish (US)
Pages (from-to)33-37
Number of pages5
JournalCurrent Directions in Psychological Science
Volume11
Issue number1
DOIs
StatePublished - Feb 1 2002

Keywords

  • Etiology
  • Neurodevelopment
  • Predisposition
  • Schizophrenia

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