Cerebrovascularis támadáspontú gyógyszerek szabadgyökfogó hatásának vizsgálata.

Translated title of the contribution: Scavenger effect of various cerebrovascular drugs

Beáta Horváth, Zsolt Márton, Róbert Halmosi, Tamás Alexy, László Szapáry, Judit Vékási, Zsolt Bíró, Tamás Habon, Gábor Késmárky, Kálmán Tóth

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

INTRODUCTION: Oxygen free radicals play an important role in several physiological and pathophysiological processes. In pathological circumstances they can modify and damage biological systems. As oxygen free radicals are involved in a wide range of diseases (cerebrovascular, cardiovascular, etc.), scavenging these radicals should be considered as an important therapeutic approach. AIM: In our in vitro study the antioxidant capacity of three cerebrovascular drugs (pentoxiphylline, piracetam and vinpocetine) was investigated. METHODS: Phenazine methosulphate (PMS) was applied to generate free radicals and thus increased red blood cell rigidity. Filtration technique and potassium leaking were used to detect the cellular damage and the scavenging effect of the examined drugs. RESULTS: At therapeutic serum concentration only vinpocetine had significant (p < 0.01) scavenging activity which protective effect was even better at higher concentrations. Pentoxiphylline and piracetam did not have significant antioxidant capacity at therapeutic concentrations, but increasing the concentrations (pentoxiphylline at hundred times, while piracetam at ten times higher concentrations) led to a significant (p < 0.01) scavenger effect. CONCLUSION: The authors' findings suggest that this pronounced antioxidant effect of vinpocetine and even the milder scavenging capacity of piracetam which tends to cumulate in the cerebral tissue may be of value in the treatment of patients with cerebrovascular disorders.

Translated title of the contributionScavenger effect of various cerebrovascular drugs
Original languageHungarian
Pages (from-to)13-17
Number of pages5
JournalOrvosi hetilap
Volume143
Issue number1
StatePublished - Jan 6 2002

Fingerprint Dive into the research topics of 'Scavenger effect of various cerebrovascular drugs'. Together they form a unique fingerprint.

Cite this