Scalable syntheses of the BET bromodomain inhibitor JQ1

Keyphrases

• Scalable Synthesis 100%
• JQ-1 100%
• BET Bromodomain Inhibitor 100%
• Safer Reagent 100%
• Benzodiazepines 50%
• Triazole 50%
• Good Yield 50%
• Purification Process 50%
• Diphenyl 50%
• Toxic Reagent 50%
• Enantiomeric Purity 50%
• Thioamide 50%
• Three-step Method 50%
• Amidrazones 50%
• Enantiomerically Enriched 50%
• Lawesson's Reagent 50%
• Diethyl Chlorophosphate 50%
• Triazole Formation 50%

Chemistry

• JQ1 100%
• Triazole 40%
• Enantiomer 20%
• Toxic 20%
• Benzodiazepine 20%