Scaffolding actions of membrane-associated progesterone receptors

Christy R. Hagan, Emily J. Faivre, Carol A. Lange

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

Progesterone is an ovarian steroid hormone that is essential for normal breast development. The actions of progesterone are largely mediated through binding to its cognate steroid hormone receptor, the progesterone receptor (PR). PR isoforms exist in the nucleus and transcriptionally activate genes necessary for proliferation and survival (classical role). Cytoplasmic or membrane-associated PR exists in the cytoplasm where it participates in protein complexes with signaling molecules and other steroid hormone receptors capable of rapid activation of cytoplasmic protein kinase cascades. This review details the extra nuclear scaffolding actions of PR with c-Src and MEK1, the upstream components of MAP kinase modules.

Original languageEnglish (US)
Pages (from-to)568-572
Number of pages5
JournalSteroids
Volume74
Issue number7
DOIs
StatePublished - Jul 2009

Keywords

  • CD domain
  • MEK1
  • Progesterone receptor
  • Rapid kinase activation
  • Scaffold
  • c-Src

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