Spinocerebellar ataxia type 8 (SCA8) is a slowly progressive, dominantly inherited neurodegenerative disease. SCA8 patients have large CTG repeat expansions in the untranslated antisense RNA of the Kelch-like 1 gene (KLHL1AS), but the precise relationship between this expansion and disease is complex and is still poorly understood.
|Original language||English (US)|
|Title of host publication||Encyclopedia of Movement Disorders|
|Number of pages||3|
|State||Published - Jan 1 2010|
- Antisense RNA
- Spinocerebellar ataxia
- Trinucleotide expansion mutation