SARS-CoV-2 Vaccination IgG Antibody Responses in Patients with Hematologic Malignancies in a Myeloid Enriched Cohort: A Single Center Observation

Fieke W. Hoff; Suleyman Y. Goksu; Naveen Premnath; Prapti A. Patel; Ruth Ikpefan; Gurbakhash Kaur; Madhuri Vusirikala; Taha Bat; Weina Chen; Praveen Ramakrishnan Geethakumari; Larry D. Anderson; Farrukh T. Awan; Robert H. Collins; Olga K. Weinberg; Alagarraju Muthukumar; Stephen S. Chung; Yazan F. Madanat

doi:10.5644/ama2006-124.399

SARS-CoV-2 Vaccination IgG Antibody Responses in Patients with Hematologic Malignancies in a Myeloid Enriched Cohort: A Single Center Observation

Fieke W. Hoff, Suleyman Y. Goksu, Naveen Premnath, Prapti A. Patel, Ruth Ikpefan, Gurbakhash Kaur, Madhuri Vusirikala, Taha Bat, Weina Chen, Praveen Ramakrishnan Geethakumari, Larry D. Anderson, Farrukh T. Awan, Robert H. Collins, Olga K. Weinberg, Alagarraju Muthukumar, Stephen S. Chung, Yazan F. Madanat

Research output: Contribution to journal › Article › peer-review

Abstract

Objective. Patients diagnosed with hematologic malignancies are at increased risk for severe SARS-CoV-2 infection. We evaluated the serological IgG response following two doses of the SARS-CoV-2 vaccine in patients with hematologic malig-nancies. Methods. Patients treated at UT Southwestern Medical Center with a diagnosis of a myeloid or lymphoid neoplasm were included. SARS-CoV-2 vaccination response was defined as a positive quantifiable spike IgG antibody titer. Results. Sixty patients were included in the study and 60% were diagnosed with a myeloid neoplasm. The majority (85%) of the patients with a myeloid malignancy and 50% of the patients with a lymphoid malignancy mounted a serological response after receiving two doses of the vaccine. Conclusion. Vaccination should be offered irrespective of ongoing treatment or active disease. Findings require validation in a larger cohort of patients.

Original language	English (US)
Pages (from-to)	30-36
Number of pages	7
Journal	Acta medica academica
Volume	52
Issue number	1
DOIs	https://doi.org/10.5644/ama2006-124.399
State	Published - 2023
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2023 Hoff et al.

Keywords

Antibody Response
Hematologic Malignancy
SARS-CoV-2 Vaccination

PubMed: MeSH publication types

Journal Article

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Hoff, F. W., Goksu, S. Y., Premnath, N., Patel, P. A., Ikpefan, R., Kaur, G., Vusirikala, M., Bat, T., Chen, W., Geethakumari, P. R., Anderson, L. D., Awan, F. T., Collins, R. H., Weinberg, O. K., Muthukumar, A., Chung, S. S., & Madanat, Y. F. (2023). SARS-CoV-2 Vaccination IgG Antibody Responses in Patients with Hematologic Malignancies in a Myeloid Enriched Cohort: A Single Center Observation. Acta medica academica, 52(1), 30-36. https://doi.org/10.5644/ama2006-124.399

Hoff, FW, Goksu, SY, Premnath, N, Patel, PA, Ikpefan, R, Kaur, G, Vusirikala, M, Bat, T, Chen, W, Geethakumari, PR, Anderson, LD, Awan, FT, Collins, RH, Weinberg, OK, Muthukumar, A, Chung, SS & Madanat, YF 2023, 'SARS-CoV-2 Vaccination IgG Antibody Responses in Patients with Hematologic Malignancies in a Myeloid Enriched Cohort: A Single Center Observation', Acta medica academica, vol. 52, no. 1, pp. 30-36. https://doi.org/10.5644/ama2006-124.399

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abstract = "Objective. Patients diagnosed with hematologic malignancies are at increased risk for severe SARS-CoV-2 infection. We evaluated the serological IgG response following two doses of the SARS-CoV-2 vaccine in patients with hematologic malig-nancies. Methods. Patients treated at UT Southwestern Medical Center with a diagnosis of a myeloid or lymphoid neoplasm were included. SARS-CoV-2 vaccination response was defined as a positive quantifiable spike IgG antibody titer. Results. Sixty patients were included in the study and 60% were diagnosed with a myeloid neoplasm. The majority (85%) of the patients with a myeloid malignancy and 50% of the patients with a lymphoid malignancy mounted a serological response after receiving two doses of the vaccine. Conclusion. Vaccination should be offered irrespective of ongoing treatment or active disease. Findings require validation in a larger cohort of patients.",

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doi = "10.5644/ama2006-124.399",

language = "English (US)",

volume = "52",

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T2 - A Single Center Observation

AU - Hoff, Fieke W.

AU - Goksu, Suleyman Y.

AU - Premnath, Naveen

AU - Patel, Prapti A.

AU - Ikpefan, Ruth

AU - Kaur, Gurbakhash

AU - Vusirikala, Madhuri

AU - Bat, Taha

AU - Chen, Weina

AU - Geethakumari, Praveen Ramakrishnan

AU - Anderson, Larry D.

AU - Awan, Farrukh T.

AU - Collins, Robert H.

AU - Weinberg, Olga K.

AU - Muthukumar, Alagarraju

AU - Chung, Stephen S.

AU - Madanat, Yazan F.

PY - 2023

Y1 - 2023

N2 - Objective. Patients diagnosed with hematologic malignancies are at increased risk for severe SARS-CoV-2 infection. We evaluated the serological IgG response following two doses of the SARS-CoV-2 vaccine in patients with hematologic malig-nancies. Methods. Patients treated at UT Southwestern Medical Center with a diagnosis of a myeloid or lymphoid neoplasm were included. SARS-CoV-2 vaccination response was defined as a positive quantifiable spike IgG antibody titer. Results. Sixty patients were included in the study and 60% were diagnosed with a myeloid neoplasm. The majority (85%) of the patients with a myeloid malignancy and 50% of the patients with a lymphoid malignancy mounted a serological response after receiving two doses of the vaccine. Conclusion. Vaccination should be offered irrespective of ongoing treatment or active disease. Findings require validation in a larger cohort of patients.

AB - Objective. Patients diagnosed with hematologic malignancies are at increased risk for severe SARS-CoV-2 infection. We evaluated the serological IgG response following two doses of the SARS-CoV-2 vaccine in patients with hematologic malig-nancies. Methods. Patients treated at UT Southwestern Medical Center with a diagnosis of a myeloid or lymphoid neoplasm were included. SARS-CoV-2 vaccination response was defined as a positive quantifiable spike IgG antibody titer. Results. Sixty patients were included in the study and 60% were diagnosed with a myeloid neoplasm. The majority (85%) of the patients with a myeloid malignancy and 50% of the patients with a lymphoid malignancy mounted a serological response after receiving two doses of the vaccine. Conclusion. Vaccination should be offered irrespective of ongoing treatment or active disease. Findings require validation in a larger cohort of patients.

KW - Antibody Response

KW - Hematologic Malignancy

KW - SARS-CoV-2 Vaccination

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SARS-CoV-2 Vaccination IgG Antibody Responses in Patients with Hematologic Malignancies in a Myeloid Enriched Cohort: A Single Center Observation

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

Publisher link

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