Sarcoid Transformation at Wound Sites

Derek C. Knottenbelt, John Schumacher, Ferenc Toth

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Equine sarcoids are likely caused by bovine papillomavirus. Sarcoid-affected horses are capable of transmitting the virus, often by flies, to other horses to cause development of sarcoids. Early signs that a sarcoid is developing within a wound are dehiscence, unhealthy appearance of granulation tissue, lack of wound contraction, and inability to control exuberant granulation tissue. Sarcoids in a wound are difficult to diagnose histologically because sarcoid tissue is often admixed with granulation tissue. Pathologists unfamiliar with the histological appearance of sarcoids often misdiagnose the lesion. Recurrence of a sarcoid after simple surgical excision is common. Other treatments that may offer better success than excision include: cryotherapy; laser surgical excision; immunotherapy in in form of cell-wall extracts of mycobacteria or subcutaneous implantation of sarcoid tissue; repeated topical application of a cytotoxic drug, such as cisplatin, administered alone or in combination with electric-impulse therapy, the anti-mitotic drug, 5-flurouracil, or an antiviral ointment, such as acyclovir or imiquimod; and radiation therapy. Sarcoid contamination of wounds can be prevented by covering wounds, if possible, and by fly control.

Original languageEnglish (US)
Title of host publicationEquine Wound Management
Subtitle of host publicationThird Edition
PublisherWiley-Blackwell
Pages490-507
Number of pages18
ISBN (Electronic)9781118999219
ISBN (Print)9781118999257
DOIs
StatePublished - Nov 9 2016

Keywords

  • Bovine papillomavirus
  • Sarcoid
  • Wound

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