Salvage therapy of open, infected surgical wounds: a retrospective review using Techni-Care.

B. C. Grubbs, C. L. Statz, E. M. Johnson, M. E. Uknis, J. T. Lee, D. L. Dunn

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

OBJECTIVE: To determine outcome of infected surgical wounds treated with 3% para-chloro-meta-xylenol + 3% phospholipid PTC [PCMX-PL] (Techni-Care). DESIGN: Retrospective review of patient records. SETTING: University hospital. PATIENTS: Thirty consecutively treated patients (sixteen male, fourteen female) who had developed open infected wounds (twenty-one abdominal [seventy percent], nine extremity [thirty percent]). Mean patient age was 50.1 years. All wounds were treated with commonly practiced wound care techniques (e.g., debridement, frequent dressing changes using saline or topical antibiotics, and, in most cases, parenteral antibiotics) for an extended period of time prior to intervention (mean = 35 days). INTERVENTIONS: PCMX-PL, a topical microbicide, was used as adjunctive therapy. Eight outcome parameters were analyzed: (1) patient morbidity and mortality; (2) wound healing; (3) number of debridements; (4) wound culture results; (5) leukocytosis (peripheral white blood cell count > 10,000 cells/microl); (6) number of febrile days (temperature > 101 degrees F); (7) length of hospital stay; and (8) number of days of intensive care. RESULTS: No treatment failures or adverse reactions to PCMX-PL were seen. Twenty (sixty-seven percent) wounds were healed or had been successfully closed while ten (thirty-three percent) were granulating well at sixty-day follow-up. The number of debridements, positive wound cultures, white-blood-cells, and febrile days decreased after PCMX-PL treatment began. CONCLUSIONS: Despite severe underlying diseases, all patients were discharged from the hospital with closed or healing wounds. We recommend treatment with PCMX-PL as an adjunctive therapy for infected wounds particularly when standard care measures have failed.

Original languageEnglish (US)
Pages (from-to)109-114
Number of pages6
JournalSurgical Infections
Volume1
Issue number2
DOIs
StatePublished - Jan 1 2000

Fingerprint

Salvage Therapy
Factor IX
Phospholipids
Wounds and Injuries
Debridement
Wound Healing
Length of Stay
Fever
Anti-Bacterial Agents
Local Anti-Infective Agents
Leukocytosis
Therapeutics
Critical Care
Bandages
Surgical Wound
Treatment Failure
Leukocyte Count
Leukocytes
Extremities
3,5-xylenol

Cite this

Grubbs, B. C., Statz, C. L., Johnson, E. M., Uknis, M. E., Lee, J. T., & Dunn, D. L. (2000). Salvage therapy of open, infected surgical wounds: a retrospective review using Techni-Care. Surgical Infections, 1(2), 109-114. https://doi.org/10.1089/109629600321146

Salvage therapy of open, infected surgical wounds : a retrospective review using Techni-Care. / Grubbs, B. C.; Statz, C. L.; Johnson, E. M.; Uknis, M. E.; Lee, J. T.; Dunn, D. L.

In: Surgical Infections, Vol. 1, No. 2, 01.01.2000, p. 109-114.

Research output: Contribution to journalArticle

Grubbs, BC, Statz, CL, Johnson, EM, Uknis, ME, Lee, JT & Dunn, DL 2000, 'Salvage therapy of open, infected surgical wounds: a retrospective review using Techni-Care.', Surgical Infections, vol. 1, no. 2, pp. 109-114. https://doi.org/10.1089/109629600321146
Grubbs, B. C. ; Statz, C. L. ; Johnson, E. M. ; Uknis, M. E. ; Lee, J. T. ; Dunn, D. L. / Salvage therapy of open, infected surgical wounds : a retrospective review using Techni-Care. In: Surgical Infections. 2000 ; Vol. 1, No. 2. pp. 109-114.
@article{e932e625840948848d307a2f43363634,
title = "Salvage therapy of open, infected surgical wounds: a retrospective review using Techni-Care.",
abstract = "OBJECTIVE: To determine outcome of infected surgical wounds treated with 3{\%} para-chloro-meta-xylenol + 3{\%} phospholipid PTC [PCMX-PL] (Techni-Care). DESIGN: Retrospective review of patient records. SETTING: University hospital. PATIENTS: Thirty consecutively treated patients (sixteen male, fourteen female) who had developed open infected wounds (twenty-one abdominal [seventy percent], nine extremity [thirty percent]). Mean patient age was 50.1 years. All wounds were treated with commonly practiced wound care techniques (e.g., debridement, frequent dressing changes using saline or topical antibiotics, and, in most cases, parenteral antibiotics) for an extended period of time prior to intervention (mean = 35 days). INTERVENTIONS: PCMX-PL, a topical microbicide, was used as adjunctive therapy. Eight outcome parameters were analyzed: (1) patient morbidity and mortality; (2) wound healing; (3) number of debridements; (4) wound culture results; (5) leukocytosis (peripheral white blood cell count > 10,000 cells/microl); (6) number of febrile days (temperature > 101 degrees F); (7) length of hospital stay; and (8) number of days of intensive care. RESULTS: No treatment failures or adverse reactions to PCMX-PL were seen. Twenty (sixty-seven percent) wounds were healed or had been successfully closed while ten (thirty-three percent) were granulating well at sixty-day follow-up. The number of debridements, positive wound cultures, white-blood-cells, and febrile days decreased after PCMX-PL treatment began. CONCLUSIONS: Despite severe underlying diseases, all patients were discharged from the hospital with closed or healing wounds. We recommend treatment with PCMX-PL as an adjunctive therapy for infected wounds particularly when standard care measures have failed.",
author = "Grubbs, {B. C.} and Statz, {C. L.} and Johnson, {E. M.} and Uknis, {M. E.} and Lee, {J. T.} and Dunn, {D. L.}",
year = "2000",
month = "1",
day = "1",
doi = "10.1089/109629600321146",
language = "English (US)",
volume = "1",
pages = "109--114",
journal = "Surgical Infections",
issn = "1096-2964",
publisher = "Mary Ann Liebert Inc.",
number = "2",

}

TY - JOUR

T1 - Salvage therapy of open, infected surgical wounds

T2 - a retrospective review using Techni-Care.

AU - Grubbs, B. C.

AU - Statz, C. L.

AU - Johnson, E. M.

AU - Uknis, M. E.

AU - Lee, J. T.

AU - Dunn, D. L.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - OBJECTIVE: To determine outcome of infected surgical wounds treated with 3% para-chloro-meta-xylenol + 3% phospholipid PTC [PCMX-PL] (Techni-Care). DESIGN: Retrospective review of patient records. SETTING: University hospital. PATIENTS: Thirty consecutively treated patients (sixteen male, fourteen female) who had developed open infected wounds (twenty-one abdominal [seventy percent], nine extremity [thirty percent]). Mean patient age was 50.1 years. All wounds were treated with commonly practiced wound care techniques (e.g., debridement, frequent dressing changes using saline or topical antibiotics, and, in most cases, parenteral antibiotics) for an extended period of time prior to intervention (mean = 35 days). INTERVENTIONS: PCMX-PL, a topical microbicide, was used as adjunctive therapy. Eight outcome parameters were analyzed: (1) patient morbidity and mortality; (2) wound healing; (3) number of debridements; (4) wound culture results; (5) leukocytosis (peripheral white blood cell count > 10,000 cells/microl); (6) number of febrile days (temperature > 101 degrees F); (7) length of hospital stay; and (8) number of days of intensive care. RESULTS: No treatment failures or adverse reactions to PCMX-PL were seen. Twenty (sixty-seven percent) wounds were healed or had been successfully closed while ten (thirty-three percent) were granulating well at sixty-day follow-up. The number of debridements, positive wound cultures, white-blood-cells, and febrile days decreased after PCMX-PL treatment began. CONCLUSIONS: Despite severe underlying diseases, all patients were discharged from the hospital with closed or healing wounds. We recommend treatment with PCMX-PL as an adjunctive therapy for infected wounds particularly when standard care measures have failed.

AB - OBJECTIVE: To determine outcome of infected surgical wounds treated with 3% para-chloro-meta-xylenol + 3% phospholipid PTC [PCMX-PL] (Techni-Care). DESIGN: Retrospective review of patient records. SETTING: University hospital. PATIENTS: Thirty consecutively treated patients (sixteen male, fourteen female) who had developed open infected wounds (twenty-one abdominal [seventy percent], nine extremity [thirty percent]). Mean patient age was 50.1 years. All wounds were treated with commonly practiced wound care techniques (e.g., debridement, frequent dressing changes using saline or topical antibiotics, and, in most cases, parenteral antibiotics) for an extended period of time prior to intervention (mean = 35 days). INTERVENTIONS: PCMX-PL, a topical microbicide, was used as adjunctive therapy. Eight outcome parameters were analyzed: (1) patient morbidity and mortality; (2) wound healing; (3) number of debridements; (4) wound culture results; (5) leukocytosis (peripheral white blood cell count > 10,000 cells/microl); (6) number of febrile days (temperature > 101 degrees F); (7) length of hospital stay; and (8) number of days of intensive care. RESULTS: No treatment failures or adverse reactions to PCMX-PL were seen. Twenty (sixty-seven percent) wounds were healed or had been successfully closed while ten (thirty-three percent) were granulating well at sixty-day follow-up. The number of debridements, positive wound cultures, white-blood-cells, and febrile days decreased after PCMX-PL treatment began. CONCLUSIONS: Despite severe underlying diseases, all patients were discharged from the hospital with closed or healing wounds. We recommend treatment with PCMX-PL as an adjunctive therapy for infected wounds particularly when standard care measures have failed.

UR - http://www.scopus.com/inward/record.url?scp=0034212096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034212096&partnerID=8YFLogxK

U2 - 10.1089/109629600321146

DO - 10.1089/109629600321146

M3 - Article

C2 - 12594898

AN - SCOPUS:0034212096

VL - 1

SP - 109

EP - 114

JO - Surgical Infections

JF - Surgical Infections

SN - 1096-2964

IS - 2

ER -