TY - JOUR
T1 - Salivary levels of anticonvulsants
T2 - A practical approach to drug monitoring
AU - McAuliffe, John J.
AU - Sherwin, Allan L.
AU - Leppik, Ilo E.
AU - Fayle, Shirley A.
AU - Pippenger, Charles E.
PY - 1977/5
Y1 - 1977/5
N2 - Phenobarbital, phenytoin, carbamazepine, primidone, and ethosuximide were measured in saliva and plasma obtained simultaneously from 115 patients. A method to correct for the effect of salivary pH on phenobarbital concentration of saliva was developed. Salivary concentrations of these drugs were found to be equivalent to the plasma free drug and to correlate closely with the total plasma levels. Expressed as percent of total plasma drug, the salivary (S) and plasma free (P) concentrations were: phenytoin, S 11.1 ± 2.0 percent (mean ± SD), P 10.1 ± 2.4 percent (r = 0.97); carbamazepine, S 26.0 ± 2.4 percent, P 25.9 ± 3.4 percent (r = 0.97); phenobarbital, S 43.1 ± 5.2 percent, P 40.8 ± 7.9 percent (r = 0.91); primidone, S 75.4 ± 24.9 percent, P 66.4 ± 8.8 percent (r = 0.76). Ethosuximide was not bound by plasma proteins, and its plasma and salivary levels were equal.
AB - Phenobarbital, phenytoin, carbamazepine, primidone, and ethosuximide were measured in saliva and plasma obtained simultaneously from 115 patients. A method to correct for the effect of salivary pH on phenobarbital concentration of saliva was developed. Salivary concentrations of these drugs were found to be equivalent to the plasma free drug and to correlate closely with the total plasma levels. Expressed as percent of total plasma drug, the salivary (S) and plasma free (P) concentrations were: phenytoin, S 11.1 ± 2.0 percent (mean ± SD), P 10.1 ± 2.4 percent (r = 0.97); carbamazepine, S 26.0 ± 2.4 percent, P 25.9 ± 3.4 percent (r = 0.97); phenobarbital, S 43.1 ± 5.2 percent, P 40.8 ± 7.9 percent (r = 0.91); primidone, S 75.4 ± 24.9 percent, P 66.4 ± 8.8 percent (r = 0.76). Ethosuximide was not bound by plasma proteins, and its plasma and salivary levels were equal.
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U2 - 10.1212/wnl.27.5.409
DO - 10.1212/wnl.27.5.409
M3 - Article
C2 - 16232
AN - SCOPUS:0017683153
SN - 0028-3878
VL - 27
SP - 409
EP - 413
JO - Neurology
JF - Neurology
IS - 5
ER -