Salivary CA130 with and without unilateral autonomic parotid denervation of rats fed different diets

Dorthea Johnson-Alvares, Germaine G Cornelissen-Guillaume, Ana Portela, Erna Halberg, Joel D Rudney, Chih Ko Yeh, Michael Dodds, Erhard Haus, Erwin Schaffer, Mikhail Blank, Franz Halberg

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background. Tumor markers such as CA130 can be determined in human whole saliva. Saliva represents an attractive body fluid for longitudinal studies. Materials and methods. CA130 was determined in parotid saliva from 8 rats fed different diets, with or without autonomic denervation. Results. CA130 could be determined in parotid saliva of rats, irrespective of diet and/or autonomic denervation. Whether the numerical decrease in CA130 observed after autonomic denervation is statistically significant requires further work. Conclusions. Since salivary CA130 has been shown to decrease following treatment with anti-cancer drugs in humans, the ability to determine this tumor marker in rat saliva opens new opportunities for optimizing cancer chronotherapy in the experimental laboratory.

Original languageEnglish (US)
Pages (from-to)25-28
Number of pages4
JournalIn Vivo
Volume16
Issue number1
StatePublished - May 6 2002

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Autonomic Denervation
Nutrition
Saliva
Rats
Tumor Biomarkers
Diet
Body fluids
Chronotherapy
Body Fluids
Longitudinal Studies
Neoplasms
Pharmaceutical Preparations

Keywords

  • CA130
  • Diet
  • Parotid denervation
  • Rat
  • Saliva

Cite this

Salivary CA130 with and without unilateral autonomic parotid denervation of rats fed different diets. / Johnson-Alvares, Dorthea; Cornelissen-Guillaume, Germaine G; Portela, Ana; Halberg, Erna; Rudney, Joel D; Yeh, Chih Ko; Dodds, Michael; Haus, Erhard; Schaffer, Erwin; Blank, Mikhail; Halberg, Franz.

In: In Vivo, Vol. 16, No. 1, 06.05.2002, p. 25-28.

Research output: Contribution to journalArticle

Johnson-Alvares, D, Cornelissen-Guillaume, GG, Portela, A, Halberg, E, Rudney, JD, Yeh, CK, Dodds, M, Haus, E, Schaffer, E, Blank, M & Halberg, F 2002, 'Salivary CA130 with and without unilateral autonomic parotid denervation of rats fed different diets', In Vivo, vol. 16, no. 1, pp. 25-28.
Johnson-Alvares, Dorthea ; Cornelissen-Guillaume, Germaine G ; Portela, Ana ; Halberg, Erna ; Rudney, Joel D ; Yeh, Chih Ko ; Dodds, Michael ; Haus, Erhard ; Schaffer, Erwin ; Blank, Mikhail ; Halberg, Franz. / Salivary CA130 with and without unilateral autonomic parotid denervation of rats fed different diets. In: In Vivo. 2002 ; Vol. 16, No. 1. pp. 25-28.
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AU - Halberg, Erna

AU - Rudney, Joel D

AU - Yeh, Chih Ko

AU - Dodds, Michael

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AU - Blank, Mikhail

AU - Halberg, Franz

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