TY - JOUR
T1 - Saliva Lab-on-a-chip biosensors
T2 - Recent novel ideas and applications in disease detection
AU - Haji Mohammadi, Melika
AU - Mulder, Sterre
AU - Khashayar, Patricia
AU - Kalbasi, Alireza
AU - Azimzadeh, Mostafa
AU - Aref, Amir Reza
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/9
Y1 - 2021/9
N2 - Lab-on-a-chip (LOC) devices have revolutionized the metabolic detection field by bringing together the advantages of biosensors and microfluidics in a single chip. Saliva, which contains a variety of biomarkers, has recently been recognized as a non-invasive biofluidic alternative for many diagnostic purposes. Hence, the application of LOCs for saliva analysis can be a promising diagnostic technique for a wide range of medical situations and diseases. Herein we present a review on the LOCs applied so far for diseases detection using saliva and future horizons. In this regard, after a brief introduction of LOC and saliva, a list of novel LOCs designed or used for the detection of different bacteria and viruses, cytokines, metabolites, kidney related diseases, prostate cancer and oral diseases along with their pros and cons is provided. We are also going to report how these advancements could help with the current pandemic.
AB - Lab-on-a-chip (LOC) devices have revolutionized the metabolic detection field by bringing together the advantages of biosensors and microfluidics in a single chip. Saliva, which contains a variety of biomarkers, has recently been recognized as a non-invasive biofluidic alternative for many diagnostic purposes. Hence, the application of LOCs for saliva analysis can be a promising diagnostic technique for a wide range of medical situations and diseases. Herein we present a review on the LOCs applied so far for diseases detection using saliva and future horizons. In this regard, after a brief introduction of LOC and saliva, a list of novel LOCs designed or used for the detection of different bacteria and viruses, cytokines, metabolites, kidney related diseases, prostate cancer and oral diseases along with their pros and cons is provided. We are also going to report how these advancements could help with the current pandemic.
KW - Biosensor
KW - Disease
KW - lab-on-a-chip (LOC)
KW - Metabolic
KW - Saliva
UR - http://www.scopus.com/inward/record.url?scp=85107640828&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85107640828&partnerID=8YFLogxK
U2 - 10.1016/j.microc.2021.106506
DO - 10.1016/j.microc.2021.106506
M3 - Article
AN - SCOPUS:85107640828
SN - 0026-265X
VL - 168
JO - Microchemical Journal
JF - Microchemical Journal
M1 - 106506
ER -