Safety of tiagabine: Summary of 53 trials

Ilo E. Leppik; Lennart Gram; Roger Deaton; Kenneth W. Sommerville

doi:10.1016/S0920-1211(98)00094-1

Safety of tiagabine: Summary of 53 trials

Ilo E. Leppik
, Lennart Gram
, Roger Deaton
, Kenneth W. Sommerville

Experimental and Clinical Pharmacology

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

We reviewed the clinical safety of tiagabine HCI (TGB), a selective CNS GABA uptake inhibitor, in nearly 3100 patients from 53 separate clinical trials. TGB was found to have no clinically important effect upon hepatic metabolic processes, serum concentrations of concomitant antiepileptic drugs (AEDs), laboratory values, or important interactions with any common non- AEDs. Adverse effects were usually mild and involved the nervous system. TGB is safe and well-tolerated as add-on therapy for the treatment of partial seizures.

Original language	English (US)
Pages (from-to)	235-246
Number of pages	12
Journal	Epilepsy Research
Volume	33
Issue number	2-3
DOIs	https://doi.org/10.1016/S0920-1211(98)00094-1
State	Published - Feb 1999

Bibliographical note

Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.

Keywords

Epilepsy
GABA
Safety
TGB

Publisher link

10.1016/S0920-1211(98)00094-1

Find It

Find It at U of M Libraries

Cite this

@article{2732a416c0c94a8b9d1bcf3cd6280e53,

title = "Safety of tiagabine: Summary of 53 trials",

abstract = "We reviewed the clinical safety of tiagabine HCI (TGB), a selective CNS GABA uptake inhibitor, in nearly 3100 patients from 53 separate clinical trials. TGB was found to have no clinically important effect upon hepatic metabolic processes, serum concentrations of concomitant antiepileptic drugs (AEDs), laboratory values, or important interactions with any common non- AEDs. Adverse effects were usually mild and involved the nervous system. TGB is safe and well-tolerated as add-on therapy for the treatment of partial seizures.",

keywords = "Epilepsy, GABA, Safety, TGB",

author = "Leppik, \{Ilo E.\} and Lennart Gram and Roger Deaton and Sommerville, \{Kenneth W.\}",

year = "1999",

month = feb,

doi = "10.1016/S0920-1211(98)00094-1",

language = "English (US)",

volume = "33",

pages = "235--246",

journal = "Epilepsy Research",

issn = "0920-1211",

publisher = "Elsevier BV",

number = "2-3",

}

TY - JOUR

T1 - Safety of tiagabine

T2 - Summary of 53 trials

AU - Leppik, Ilo E.

AU - Gram, Lennart

AU - Deaton, Roger

AU - Sommerville, Kenneth W.

PY - 1999/2

Y1 - 1999/2

N2 - We reviewed the clinical safety of tiagabine HCI (TGB), a selective CNS GABA uptake inhibitor, in nearly 3100 patients from 53 separate clinical trials. TGB was found to have no clinically important effect upon hepatic metabolic processes, serum concentrations of concomitant antiepileptic drugs (AEDs), laboratory values, or important interactions with any common non- AEDs. Adverse effects were usually mild and involved the nervous system. TGB is safe and well-tolerated as add-on therapy for the treatment of partial seizures.

AB - We reviewed the clinical safety of tiagabine HCI (TGB), a selective CNS GABA uptake inhibitor, in nearly 3100 patients from 53 separate clinical trials. TGB was found to have no clinically important effect upon hepatic metabolic processes, serum concentrations of concomitant antiepileptic drugs (AEDs), laboratory values, or important interactions with any common non- AEDs. Adverse effects were usually mild and involved the nervous system. TGB is safe and well-tolerated as add-on therapy for the treatment of partial seizures.

KW - Epilepsy

KW - GABA

KW - Safety

KW - TGB

UR - https://www.scopus.com/pages/publications/0033034045

UR - https://www.scopus.com/pages/publications/0033034045#tab=citedBy

U2 - 10.1016/S0920-1211(98)00094-1

DO - 10.1016/S0920-1211(98)00094-1

M3 - Article

C2 - 10094434

AN - SCOPUS:0033034045

SN - 0920-1211

VL - 33

SP - 235

EP - 246

JO - Epilepsy Research

JF - Epilepsy Research

IS - 2-3

ER -

Safety of tiagabine: Summary of 53 trials

Abstract

Bibliographical note

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this