Safety of platelet transfusion: Past, present and future

M. C. Katus, Z. M. Szczepiorkowski, L. J. Dumont, N. M. Dunbar

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Platelet components became routinely available to many institutions in the late 1960s and since then utilization has steadily increased. Platelets are produced by three principal methods and their manufacturing process is regulated by multiple agencies. As the field of platelet transfusion has evolved, a broad array of strategies to improve platelet safety has developed. This review will explore the evolution of modern platelet component therapy, highlight the various risks associated with platelet transfusion and describe risk reduction strategies that have been implemented to improve platelet transfusion safety. In closing, the reader will be briefly introduced to select investigational platelet and platelet-mimetic products that have the potential to enhance platelet transfusion safety in the near future.

Original languageEnglish (US)
Pages (from-to)103-113
Number of pages11
JournalVox Sanguinis
Volume107
Issue number2
DOIs
StatePublished - Aug 2014

Keywords

  • Blood collection
  • Platelet concentrates
  • Platelet transfusion
  • Transfusion medicine
  • Transfusion reactions
  • Transfusion-transmissible infections

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