TY - JOUR
T1 - Safety and yield of percutaneous liver biopsy in adults and children with chronic hepatitis B
T2 - Results from a prospective, multicenter study
AU - the Hepatitis B Research Network
AU - Ghany, Marc G.
AU - Belle, Steven H.
AU - Kleiner, David E.
AU - Smith, Coleman
AU - Kelley, Stephanie S.
AU - Rosenthal, Philip
AU - Fontana, Robert J.
AU - Lau, Daryl T.Y.
AU - Chung, Raymond T.
AU - Roberts, Lewis R.
AU - Hassan, Mohamed A.
AU - Schwarzenberg, Sarah J.
AU - Di Bisceglie, Adrian M.
AU - Lisker-Melman, Mauricio
AU - Teckman, Jeffrey
AU - Janssen, Harry L.A.
AU - Wong, David K.
AU - Juan, Joshua
AU - Feld, Jordan
AU - Yim, Colina
AU - Patel, Keyur
AU - Ling, Simon C.
AU - Lee, William M.
AU - Murakami, Carol S.
AU - Perrillo, Robert
AU - Do, Son
AU - Rodriguez-Baez, Norberto
AU - Han, Steven Huy B.
AU - Tran, Tram T.
AU - Terrault, Norah A.
AU - Khalili, Mandana
AU - Cooper, Stewart L.
AU - Suk-Fong Lok, Anna
AU - Tsai, Naoky
AU - Younoszai, Barak
AU - Fried, Michael W.
AU - Evon, Donna
AU - Muir, Andrew
AU - Darling, Jama M.
AU - Carithers, Robert C.
AU - Shuhart, Margaret
AU - Kowdley, Kris V.
AU - Wang, Chia C.
AU - Murray, Karen F.
AU - Sterling, Richard K.
AU - Luketic, Velimir A.
AU - Schwarz, Kathleen B.
AU - Jake Liang, T.
AU - Hoofnagle, Jay H.
AU - Doo, Edward
N1 - Publisher Copyright:
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases.
PY - 2023/6
Y1 - 2023/6
N2 - Background: Prospective data regarding the safety and yield of liver biopsy in both adults and children with chronic hepatitis B are limited. The aim of this study is to report safety, yield, and complication rates among adults and children with chronic hepatitis B undergoing percutaneous liver biopsy. Methods: Data on the indication for procedural characteristics and complication rate for liver biopsies performed as part of the Hepatitis B Research Network were prospectively recorded on a study case report form and analyzed in aggregate. Results: Among 2506 adult and pediatric subjects enrolled in the Hepatitis B Research Network between 2011 and 2018, 465 (19%) underwent 491 liver biopsies for clinical or research reasons. Adequate liver tissue was obtained in 98% of the procedures. In total, there were 32 complications reported for 24 biopsies: 23 biopsies with 30 complications in adults and 1 biopsy with 2 complications in children. Pain (n = 19) and vasovagal reaction (n = 6) were the most common complications. There were 7 serious adverse events, including an arterioportal venous fistula, a pneumothorax, 4 cases of bleeding, and severe pain with no associated condition. There were no deaths. Conclusions: These data demonstrate that percutaneous liver biopsy is associated with a high yield of tissue (98%) and a rate of serious complications of 1.4% in both children and adults with chronic HBV. These results support the focused use of liver biopsy in the evaluation of novel treatments in development for chronic hepatitis B.
AB - Background: Prospective data regarding the safety and yield of liver biopsy in both adults and children with chronic hepatitis B are limited. The aim of this study is to report safety, yield, and complication rates among adults and children with chronic hepatitis B undergoing percutaneous liver biopsy. Methods: Data on the indication for procedural characteristics and complication rate for liver biopsies performed as part of the Hepatitis B Research Network were prospectively recorded on a study case report form and analyzed in aggregate. Results: Among 2506 adult and pediatric subjects enrolled in the Hepatitis B Research Network between 2011 and 2018, 465 (19%) underwent 491 liver biopsies for clinical or research reasons. Adequate liver tissue was obtained in 98% of the procedures. In total, there were 32 complications reported for 24 biopsies: 23 biopsies with 30 complications in adults and 1 biopsy with 2 complications in children. Pain (n = 19) and vasovagal reaction (n = 6) were the most common complications. There were 7 serious adverse events, including an arterioportal venous fistula, a pneumothorax, 4 cases of bleeding, and severe pain with no associated condition. There were no deaths. Conclusions: These data demonstrate that percutaneous liver biopsy is associated with a high yield of tissue (98%) and a rate of serious complications of 1.4% in both children and adults with chronic HBV. These results support the focused use of liver biopsy in the evaluation of novel treatments in development for chronic hepatitis B.
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U2 - 10.1097/HC9.0000000000000116
DO - 10.1097/HC9.0000000000000116
M3 - Article
C2 - 37184524
AN - SCOPUS:85184021515
SN - 2471-254X
VL - 7
JO - Hepatology Communications
JF - Hepatology Communications
IS - 6
M1 - e0116
ER -