Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement - a case series

Don Bambino Geno Tai; Nathan J Brinkman; Omar Abu Saleh; Douglas R Osmon; Matthew P Abdel; Christina G Rivera

doi:10.5194/jbji-6-147-2021

Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement - a case series

Don Bambino Geno Tai, Nathan J Brinkman, Omar Abu Saleh, Douglas R Osmon, Matthew P Abdel, Christina G Rivera

Chancellor's Office (Rochester)

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Abstract

High-dose liquid antibiotics are uncommon in bone cement. We present a case series of patients in which up to 16 mL of liquid amikacin (250 mg mL - 1 ) was successfully incorporated into bone cement to treat periprosthetic joint infections. We did not observe adverse drug reactions definitively attributed to its use.

Original language	English (US)
Pages (from-to)	147-150
Number of pages	4
Journal	Journal of Bone and Joint Infection
Volume	6
Issue number	5
DOIs	https://doi.org/10.5194/jbji-6-147-2021
State	Published - 2021

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title = "Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement - a case series",

abstract = "High-dose liquid antibiotics are uncommon in bone cement. We present a case series of patients in which up to 16 mL of liquid amikacin (250 mg mL - 1 ) was successfully incorporated into bone cement to treat periprosthetic joint infections. We did not observe adverse drug reactions definitively attributed to its use. ",

author = "Tai, {Don Bambino Geno} and Brinkman, {Nathan J} and {Abu Saleh}, Omar and Osmon, {Douglas R} and Abdel, {Matthew P} and Rivera, {Christina G}",

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AU - Abu Saleh, Omar

AU - Osmon, Douglas R

AU - Abdel, Matthew P

AU - Rivera, Christina G

PY - 2021

Y1 - 2021

N2 - High-dose liquid antibiotics are uncommon in bone cement. We present a case series of patients in which up to 16 mL of liquid amikacin (250 mg mL - 1 ) was successfully incorporated into bone cement to treat periprosthetic joint infections. We did not observe adverse drug reactions definitively attributed to its use.

AB - High-dose liquid antibiotics are uncommon in bone cement. We present a case series of patients in which up to 16 mL of liquid amikacin (250 mg mL - 1 ) was successfully incorporated into bone cement to treat periprosthetic joint infections. We did not observe adverse drug reactions definitively attributed to its use.

U2 - 10.5194/jbji-6-147-2021

DO - 10.5194/jbji-6-147-2021

M3 - Article

C2 - 34084704

SN - 2206-3552

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IS - 5

ER -

Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement - a case series

Abstract

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