Safe use of right lobe living donor livers with moderate steatosis in adult-to-adult living donor liver transplantation: a retrospective study

Young In Yoon, Gi Won Song, Sung Gyu Lee, Gil Chun Park, Shin Hwang, Ki Hun Kim, Chul Soo Ahn, Deok Bog Moon, Tae Yong Ha, Dong Hwan Jung, Kyung Won Kim, Ju Hyun Shim, Eun Young Tak, Varvara A. Kirchner, Timothy L. Pruett

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Hepatic steatosis (HS) beyond a certain degree can jeopardize living donor (LD) safety, particularly in right lobe (RL) donors, making it a major obstacle for donor pool expansion in adult-to-adult living donor liver transplantation (ALDLT). From July 2004 to June 2016, 58 LDs donated their RLs despite having moderate HS (30%-50% steatosis) determined by intraoperative biopsy at a single center. We performed greedy matching to compare the outcomes of the donors and recipients of this group with those of LDs with no HS. The mean left lobe (LL) HS value in the 58 cases was 20.9 ± 12.4%, which was significantly lower than the mean RL HS value (38.8 ± 6.7%, P < 0.001). The mean ratio of the remnant LL to the total liver volume was 37.8 ± 2.2. No differences were observed in the postoperative liver function and donor and recipient morbidity and mortality rates. The liver regeneration rates in recipients and donors at 1 month, 6 months, and 1 year postoperatively did not differ significantly. The patient and graft survival rates of the recipients showed no differences. The use of well-selected RL grafts with moderate steatosis does not impair graft function, recipient outcomes, or donor safety.

Original languageEnglish (US)
Pages (from-to)872-881
Number of pages10
JournalTransplant International
Volume34
Issue number5
Early online dateMar 4 2021
DOIs
StatePublished - May 2021

Bibliographical note

Funding Information:
This research was supported by research funds from the National Research Foundation of Korea (NRF‐2015K1A4A3046807).

Publisher Copyright:
© 2021 Steunstichting ESOT. Published by John Wiley & Sons Ltd

Keywords

  • hepatic steatosis
  • living donor liver transplantation
  • right lobe donation

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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