Sacral agenesis: evaluation of accompanying pathologies in 38 cases, with analysis of long-term outcomes

Mehmet Bülent Balioğlu, Yunus Emre Akman, Hanifi Ucpunar, Akif Albayrak, Deniz Kargın, Yunus Atıcı, Abdül Fettah Büyük

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Purpose: Sacral agenesis (SA), or caudal regression syndrome, is a congenital malformation of the spine of varying degree of severity. The aim of our study was to identify associated impairments in structure and function of the orthopedic, neurological, cardiopulmonary, genitourinary, and gastrointestinal systems, and to evaluate their impact on function. Methods: This was a retrospective case series analysis of 38 patients with SA. Patients were divided into two groups: SA with myelomeningocele (group 1) and without myelomeningocele (group 2). Between-group comparisons in terms of the features of the SA, impairments in associated systems, impact on gross motor function, need for surgery, and association with prenatal screening and maternal gestational diabetes were evaluated. Results: The majority of comorbidities were orthopedic and neurological in nature. Impairments in sphincter control and independent transferring were more prevalent in group 1, resulting in lower function. Scoliosis, kyphosis, and hip dislocation/subluxation were the most common orthopedic problems, with a higher prevalence of kyphosis in group 1. The requirement for neurosurgery was significantly higher in group 1. Conclusions: Orthopedic and neurological comorbidities are commonly associated with SA and are more prevalent in the presence of a myelomeningocele. As the impairments impact a child’s ability for maximum function, early identification and intervention is required to correct or ameliorate the impairment. Level of Evidence: Level IV.

Original languageEnglish (US)
Pages (from-to)1693-1702
Number of pages10
JournalChild's Nervous System
Issue number9
StatePublished - Sep 1 2016

Bibliographical note

Publisher Copyright:
© 2016, Springer-Verlag Berlin Heidelberg.

Copyright 2017 Elsevier B.V., All rights reserved.


  • Caudal regression syndrome
  • Congenital anomaly
  • Sacral agenesis
  • Spina bifida
  • Spinal dysraphism


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