S100A1 expression in ovarian and endometrial endometrioid carcinomas is a prognostic indicator of relapse-free survival

Melissa S. DeRycke, John D. Andersen, Katherine M. Harrington, Stefan E. Pambuccian, Steve E. Kalloger, Kristin L.M. Boylan, Peter A. Argenta, Amy P.N. Skubitz

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

We sought to investigate the expression levels of S100A1 in ovarian cancer cell lines and tissues to correlate S100A1 with subtype, stage, grade, and relapse-free survival. S100A1 messenger RNA and protein were up-regulated in ovarian cancer cell lines and tumors compared with normal ovarian cell lines and tissues by gene microarray analysis, reverse transcriptase-polymerase chain reaction, quantitative reverse transcriptase-polymerase chain reaction, and Western immunoblotting. In the study, 63.7% of serous, 21.2% of clear cell, 11.2% of endometrioid, and 3% of mucinous ovarian (1/31) cancers were S100A1+ by immunohistochemical staining of tissue microarrays (n = 500). S100A1 expression increased with increasing Silverberg grade but not stage in serous tumors. Endometrial tissue microarrays (n = 127) were 9.4% S100A1+; no correlation with stage or grade and S100A1 was found. In the endometrioid subtype of ovarian and endometrial cancers, relapse-free survival was decreased for patients with S100A1+ tumors. These data suggest that S100A1 is a marker for poor prognosis of endometrioid subtypes of cancer.

Original languageEnglish (US)
Pages (from-to)846-856
Number of pages11
JournalAmerican journal of clinical pathology
Volume132
Issue number6
DOIs
StatePublished - Dec 1 2009

Keywords

  • Endometrioid subtype
  • Gene expression
  • Ovarian cancer
  • S100A1
  • Tissue microarray

Fingerprint Dive into the research topics of 'S100A1 expression in ovarian and endometrial endometrioid carcinomas is a prognostic indicator of relapse-free survival'. Together they form a unique fingerprint.

  • Cite this