Rutin inhibits human leukemia tumor growth in a murine xenograft model in vivo

Jing Pin Lin, Jai Sing Yang, Jen Jyh Lin, Kuang Chi Lai, Hsu Feng Lu, Chia Yu Ma, Rick Sai-Chuen Wu, King Chuan Wu, Fu Shin Chueh, W. Gibson Wood, Jing Gung Chung

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Numerous studies have shown that rutin has anticancer effects. We have previously reported that rutin induced cell cycle arrest and apoptosis in murine leukemia WEHI-3 cells in vitro and in vivo. However, there are no data showing that rutin inhibits human leukemia HL-60 cells in vivo in a murine xenograft animal model. Human leukemia HL-60 cells were implanted into mice and treated with vehicle (1% DMSO), rutin (120 mg/kg of body weight) or vinblastine (120 μg/kg of body weight). Compounds and agents were injected once every four days intraperitoneally (i.p.) for 36 days. Treatment with 120 mg/kg of rutin or with 120 μg/kg of vinblastine resulted in a reduction of tumor weight and volume when compared with the control groups. Tumor size in xenograft mice treated with 120 mg/kg of rutin was significantly smaller than that in the untreated-control group. These novel findings indicate that rutin inhibits tumor growth in a xenograft animal model. Rutin may be useful in treating leukemia but certainly much more research is needed.

Original languageEnglish (US)
Pages (from-to)480-484
Number of pages5
JournalEnvironmental Toxicology
Volume27
Issue number8
DOIs
StatePublished - Aug 1 2012

Keywords

  • Human leukemia HL-60 cells
  • In vivo
  • Rutin
  • Xenograft transplantation

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