Running Out of Options: Rhabdomyolysis Associated with Cannabis Hyperemesis Syndrome

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Cannabis hyperemesis syndrome (CHS) is a condition in which some patients with long-term, frequent use of cannabis paradoxically develop recurrent episodes of nausea and vomiting. The pathophysiology underlying this condition is poorly understood, as is the explanation for its common association with patients’ discovery that hot-water bathing alleviates symptoms. We describe the case of a 24-year-old male with daily marijuana use and a history of CHS who was found to have rhabdomyolysis induced by a period of 15 h of continuous jogging after he discovered that this activity helped to alleviate his symptoms. To our knowledge, this is the first reported case of exercise-alleviated CHS symptoms, and we propose that this case provides support to the theory of redistribution of enteric blood flow as the mechanism behind the learned hot-water bathing behavior seen so commonly in CHS.

Original languageEnglish (US)
Pages (from-to)1407-1409
Number of pages3
JournalJournal of general internal medicine
Issue number12
StatePublished - Dec 1 2017

Bibliographical note

Publisher Copyright:
© 2017, Society of General Internal Medicine.


  • adverse drug effect
  • cannabis
  • cannabis hyperemesis syndrome
  • hot water
  • hyperemesis
  • rhabdomyolysis


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