TY - JOUR
T1 - RUBELLA VIRAEMIA AND ANTIBODY RESPONSES AFTER RUBELLA VACCINATION AND REIMMUNISATION
AU - Balfour, Henry H.
AU - Groth, Karl E.
AU - Edelman, Charlene K.
AU - Amren, Don P.
AU - Best, Jennifer M.
AU - Banatvala, J. E.
PY - 1981/5/16
Y1 - 1981/5/16
N2 - Eleven 4-13 year old schoolgirls, who were seronegative by haemagglutination inhibition (HI) and radioimmunoassay (RIA) tests despite having been given HPV77-DE5 vaccine 3-9 years previously, were revaccinated with RA27/3. They showed evidence of residual immunity since they had accelerated immune responses, little or no rubella-specific IgM, no viraemia, and no vaccine-induced reactions. In contrast, all but one of the five adult women who were primary vaccinees showed a more delayed immune response. Three of four women tested had viraemia and two had vaccine-induced reactions. Enhanced HI and enhanced RIA showed that many of the schoolgirls had antibody before challenge, as did a fifth adult, who also showed an accelerated immune response, yet became viraemic.
AB - Eleven 4-13 year old schoolgirls, who were seronegative by haemagglutination inhibition (HI) and radioimmunoassay (RIA) tests despite having been given HPV77-DE5 vaccine 3-9 years previously, were revaccinated with RA27/3. They showed evidence of residual immunity since they had accelerated immune responses, little or no rubella-specific IgM, no viraemia, and no vaccine-induced reactions. In contrast, all but one of the five adult women who were primary vaccinees showed a more delayed immune response. Three of four women tested had viraemia and two had vaccine-induced reactions. Enhanced HI and enhanced RIA showed that many of the schoolgirls had antibody before challenge, as did a fifth adult, who also showed an accelerated immune response, yet became viraemic.
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U2 - 10.1016/S0140-6736(81)92243-1
DO - 10.1016/S0140-6736(81)92243-1
M3 - Article
C2 - 6112449
AN - SCOPUS:0019505770
SN - 0140-6736
VL - 317
SP - 1078
EP - 1080
JO - The Lancet
JF - The Lancet
IS - 8229
ER -
