Serum specimens from 80 patients with proven rheumatoid arthritis (R.A.) were tested for the presence of rubella haemagglutination-inhibition antibody, and the results were compared with similar data on an equal number of well, non-arthritic controls and a group of 62 individuals with other forms of arthritis. All of the R.A. patients but only 86% of the two groups of controls were found to have rubella-specific antibody. These data are consistent with the hypothesis that prior infection with rubella virus or a cllosely re- lated may be the aetiological basis of rheuma- toid arthritis in persons immunologically unable to respond tp the virus infection in a normal fashion.
Bibliographical noteFunding Information:
This work was supported by Children and Youth Project no. 603, Minneapolis Health Department. We thank Dr