rTMS combined with motor learning training in healthy subjects

James R. Carey, Felipe Fregni, Alvaro Pascual-Leone

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Purpose. This study explored the effects of motor learning training combined with repetitive transcranial magnetic stimulation (rTMS) on motor performance in healthy subjects. Methods. Twenty-seven right-handed subjects were randomized to three groups: ipsilateral rTMS (IS group), contralateral rTMS (CS group), and sham rTMS (SS group). rTMS was applied for 10 minutes (1 Hz, 90% motor threshold) prior to training. Training involved 10 minutes of finger tracking with the right hand. Tracking performance was tested before, during and after training. Results. Improvement in tracking performance over the posttests was not significantly different between the CS and SS groups, whereas it was significantly lower for the IS group compared to the SS group. No difference was found across groups at retention tests. Conclusion. These findings indicate that rTMS interfered with motor performance transiently when applied ipsilateral to the training hand and had no effect when applied contralaterally. These results invite further work to determine whether the disruptive effect of ipsilateral rTMS observed here in healthy subjects, with presumably balanced interhemispheric inhibition, might translate differently to subjects with abnormal interhemispheric inhibition (stroke patients) in a way that disinhibits the ipsilesional hemisphere and improves performance in the paretic hand.

Original languageEnglish (US)
Pages (from-to)191-199
Number of pages9
JournalRestorative Neurology and Neuroscience
Issue number3
StatePublished - 2006


  • Interhemispheric inhibition
  • Motor cortex
  • Motor learning
  • Repetitive transcranial magnetic stimulation

Fingerprint Dive into the research topics of 'rTMS combined with motor learning training in healthy subjects'. Together they form a unique fingerprint.

Cite this