Round window membrane in Ménière's disease: A human temporal bone study

Shigetoshi Yoda, Sebahattin Cureoglu, Shigetaka Shimizu, Norimasa Morita, Hisaki Fukushima, Teruyuki Sato, Tamotsu Harada, Michael M. Paparella

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Objectives: To disclose the histopathologic findings of the thickness of the round window membrane and the presence of false round window membrane in Ménière's disease. Methods: Twelve temporal bones from 6 patients with bilateral Ménière's disease, 44 temporal bones from 23 patients with unilateral Ménière's disease, and 102 age-matched normal temporal bones from 56 individuals were histopathologically examined. The thickness of the round window membrane was calculated from 3 different places. In addition, the presence of false round window membrane was investigated in temporal bones with Ménière's disease and compared to the normal temporal bones. Results: A significant difference in the mean thickness of the round window membrane was observed in temporal bones with Méniè re's disease compared with normal temporal bones. There was no significant difference in the thickness of the round window membrane between the diseased side and contralateral side in patients with unilateral Ménière's disease. A false round membrane was observed in 9 (25.7%) of 35 Ménière's disease cases and in 5 (4.9%) of 102 normal temporal bones. Conclusion: The thickened nature of the round window membrane and the frequent presence of false round window membrane in patients with Ménière's disease may impede the intratympanic injection treatments. The thickened middle layer of the round window membrane may be related to perilymphatic pressure changes observed in patients with Ménière's disease.

Original languageEnglish (US)
Pages (from-to)147-151
Number of pages5
JournalOtology and Neurotology
Volume32
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • Human temporal bone
  • Ménière's disease
  • Round window membrane

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