Round window membrane and labyrinthine pathological changes: An overview

Sebahattin Cureoglu, Patricia A. Schachern, Alessandra Rinaldo, Vladimir Tsuprun, Alfio Ferlito, Michael M. Paparella

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations


The round window membrane is considered the most likely pathway from the middle to the inner ear. Various substances placed in the middle ear have been seen to pass through the round window membrane. Once toxic substances or inflammatory mediators such as cytokines and nitric oxide enter the inner ear, various inner ear sequelae such as labyrinthitis, endolymphatic hydrops, sensorineural hearing loss or more insidious diseases can occur.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalActa Oto-Laryngologica
Issue number1
StatePublished - 2005


  • Inner ear
  • Labyrinthitis
  • Middle ear
  • Permeability
  • Round window membrane


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