Round and round gets you somewhere: Collective cell migration and planar polarity in elongating Drosophila egg chambers

Maureen Cetera, Sally Horne-Badovinac

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

Planar polarity is a developmental mechanism wherein individual cell behaviors are coordinated across a two-dimensional plane. A great deal of attention has been paid to the roles that the Frizzled/Strabismus and Fat/Dachsous signaling pathways play in this process; however, it is becoming increasingly clear that planar polarity can also be generated through alternate mechanisms. This review focuses on an unconventional form of planar polarity found within the follicular epithelium of the Drosophila egg chamber that helps to create the elongated shape of the egg. We highlight recent studies showing that the planar polarity in this system arises through collective migration of the follicle cells and the resulting rotational motion of the egg chamber.

Original languageEnglish (US)
Pages (from-to)10-15
Number of pages6
JournalCurrent Opinion in Genetics and Development
Volume32
DOIs
StatePublished - Jun 1 2015
Externally publishedYes

Bibliographical note

Funding Information:
We are grateful to Robert Ho and to members of the Horne-Badovinac lab for helpful discussions and critical comments on the manuscript. This work was supported by the National Institutes of Health (NIH), in part through NIH T32 GM007183 to M.C. and by NIH R01 GM094276 to S.H-B.

Publisher Copyright:
© 2015 Elsevier Ltd.

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