Root coverage with cultured gingival dermal substitute composed of gingival fibroblasts and matrix: A case series

Masashi Murata, Kazuhiro Okuda, Manabu Momose, Kentarou Kubo, Yoshimitsu Kumyanagi, Larry F. Wolff, Hiromasa Yoshie

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Cultured gingival dermal substitute (CGDS), composed of gingival fibroblasts and matrix and fabricated using tissue-engineering techniques, has been used for root coverage procedures. Fourteen sites from four patients with ≥ 2 mm of Miller Class I or II facial gingival tissue recession were treated. The autologous CGDS sheet, prepared prior to surgical treatment, was grafted over the teeth with gingival recession and then covered with a coronally positioned flap. Vertical and horizontal recession was measured at baseline (prior to the surgical procedure) and 13 to 40 weeks (average: 30.7 ± 9.6 weeks) after surgery. The average vertical and horizontal root coverage after surgery was 79.1% ± 25.7% and 75.2% ± 31.4%, respectively. Moreover, there was a significant increase of keratinized and attached gingival tissue at the final clinical evaluation compared with preoperative measurements (P < .05). These results demonstrate CGDS as a promising grafting material for use with root coverage procedures in periodontal therapy.

Original languageEnglish (US)
Pages (from-to)461-467
Number of pages7
JournalInternational Journal of Periodontics and Restorative Dentistry
Volume28
Issue number5
StatePublished - Oct 2008

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