Roles of zinc-binding domain of bacterial RNA polymerase in transcription

Yangbo Hu; Bin Liu

doi:10.1016/j.tibs.2022.03.007

Roles of zinc-binding domain of bacterial RNA polymerase in transcription

Yangbo Hu, Bin Liu

The Hormel Institute

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Transcription is an essential and multistep process carried out by RNA polymerase (RNAP). In bacterial RNAP, in addition to the catalytic core domain, multiple other conserved domains are also identified to play regulatory roles in transcription. One such domain is the zinc-binding domain (ZBD) located at the N terminus of the largest subunit β′ in bacterial RNAP, whose homolog is also reported in eukaryotic RNAPs. Recent structural and biochemical studies have revealed various key roles of the conserved β′ ZBD during different steps of transcription. In this review, we summarize recent progress on the regulatory roles of this β′ ZBD in bacterial transcription.

Original language	English (US)
Pages (from-to)	710-724
Number of pages	15
Journal	Trends in Biochemical Sciences
Volume	47
Issue number	8
DOIs	https://doi.org/10.1016/j.tibs.2022.03.007
State	Published - Aug 2022

Bibliographical note

Funding Information:
We thank Y. Yang at the Iowa State University for his critical reading of the manuscript. Y. H. is supported by National Natural Science Foundation of China [ 31870133 ], National Key R&D Program of China ( 2021YFA1300901 ) and the Young Top-notch Talent Cultivation Program of Hubei Province. B. L. is supported by Start-up funding from The Hormel Institute, University of Minnesota .

Publisher Copyright:
© 2022 The Authors

Keywords

elongation
recycling
termination and antitermination
transcription initiation
transcriptional regulation
transcription–translation coupling

PubMed: MeSH publication types

Journal Article
Review
Research Support, Non-U.S. Gov't

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10.1016/j.tibs.2022.03.007

http://www.cell.com/article/S0968000422000664/pdfLicense: CC BY

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title = "Roles of zinc-binding domain of bacterial RNA polymerase in transcription",

abstract = "Transcription is an essential and multistep process carried out by RNA polymerase (RNAP). In bacterial RNAP, in addition to the catalytic core domain, multiple other conserved domains are also identified to play regulatory roles in transcription. One such domain is the zinc-binding domain (ZBD) located at the N terminus of the largest subunit β′ in bacterial RNAP, whose homolog is also reported in eukaryotic RNAPs. Recent structural and biochemical studies have revealed various key roles of the conserved β′ ZBD during different steps of transcription. In this review, we summarize recent progress on the regulatory roles of this β′ ZBD in bacterial transcription.",

keywords = "elongation, recycling, termination and antitermination, transcription initiation, transcriptional regulation, transcription–translation coupling",

author = "Yangbo Hu and Bin Liu",

note = "Funding Information: We thank Y. Yang at the Iowa State University for his critical reading of the manuscript. Y. H. is supported by National Natural Science Foundation of China [ 31870133 ], National Key R&D Program of China ( 2021YFA1300901 ) and the Young Top-notch Talent Cultivation Program of Hubei Province. B. L. is supported by Start-up funding from The Hormel Institute, University of Minnesota . Publisher Copyright: {\textcopyright} 2022 The Authors",

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AU - Hu, Yangbo

AU - Liu, Bin

N1 - Funding Information: We thank Y. Yang at the Iowa State University for his critical reading of the manuscript. Y. H. is supported by National Natural Science Foundation of China [ 31870133 ], National Key R&D Program of China ( 2021YFA1300901 ) and the Young Top-notch Talent Cultivation Program of Hubei Province. B. L. is supported by Start-up funding from The Hormel Institute, University of Minnesota . Publisher Copyright: © 2022 The Authors

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N2 - Transcription is an essential and multistep process carried out by RNA polymerase (RNAP). In bacterial RNAP, in addition to the catalytic core domain, multiple other conserved domains are also identified to play regulatory roles in transcription. One such domain is the zinc-binding domain (ZBD) located at the N terminus of the largest subunit β′ in bacterial RNAP, whose homolog is also reported in eukaryotic RNAPs. Recent structural and biochemical studies have revealed various key roles of the conserved β′ ZBD during different steps of transcription. In this review, we summarize recent progress on the regulatory roles of this β′ ZBD in bacterial transcription.

AB - Transcription is an essential and multistep process carried out by RNA polymerase (RNAP). In bacterial RNAP, in addition to the catalytic core domain, multiple other conserved domains are also identified to play regulatory roles in transcription. One such domain is the zinc-binding domain (ZBD) located at the N terminus of the largest subunit β′ in bacterial RNAP, whose homolog is also reported in eukaryotic RNAPs. Recent structural and biochemical studies have revealed various key roles of the conserved β′ ZBD during different steps of transcription. In this review, we summarize recent progress on the regulatory roles of this β′ ZBD in bacterial transcription.

KW - elongation

KW - recycling

KW - termination and antitermination

KW - transcription initiation

KW - transcriptional regulation

KW - transcription–translation coupling

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DO - 10.1016/j.tibs.2022.03.007

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SN - 0376-5067

VL - 47

SP - 710

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JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

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ER -

Roles of zinc-binding domain of bacterial RNA polymerase in transcription

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

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