Roles of multiple accessory molecules in T-cell activation

Gijs A. van Seventer, Yoji Shimizu, Stephen Shaw

Research output: Contribution to journalArticlepeer-review

177 Scopus citations


Accessory molecules expressed on T cells can mediate adhesion between T cells and other cells, or the extracellular matrix. The same T-cell accessory molecules participate in a dialogue with their ligands (counter-receptors) on the antigen-presenting cells, and elicit signals that determine the specifics of activation and subsequent differentiation of the T cells and antigen-presenting cells.

Original languageEnglish (US)
Pages (from-to)294-303
Number of pages10
JournalCurrent Opinion in Immunology
Issue number3
StatePublished - Jun 1991

Bibliographical note

Funding Information:
We are thankful to Drs AA Brian, EA Clark, NK Damie, B Dupont, MK Jenkins, L Kouiova, P Kuhiman, PS Iinsiey, JA Ledbetter, P Moin-geon, C Morimoto, W Newman, RJ Noeile, and EL Reinhen for sharing with us unpublished data and papers prior to publication. The critical reading of the manuscript by Drs RE Gress and RJ Hodes is highly appreciated. GA van Seventer is a visiting associate supported by the Fogarty Exchange Program. Y Shimizu was supported by Damon-Runyon Waiter Wiicheii Cancer Research Fund Postdoctoral Fellowship DRG-993.


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