Roles of Krüppel-like factors in lymphocytes

Kensuke Takada; Kristin A. Hogquist; Stephen C. Jameson

doi:10.1007/978-4-431-87775-2_7

Roles of Krüppel-like factors in lymphocytes

Kensuke Takada, Kristin A. Hogquist, Stephen C. Jameson

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Several family members of Krüppel-like factors (KLFs) are found in lymphocytes, and their expression is tightly regulated during development and differentiation. The related factors KLF2 and KLF4 have been suggested to promote lymphocyte quiescence by inducing withdrawal of cells from the cell cycle. Although the physiological role of KLF2 in cell cycle control in lymphocytes is currently unclear, it is potentially due to redundancy between related KLFs. On the other hand, there is growing evidence that individual KLFs regulate migration of lymphocytes (and other cells) during normal homeostasis of the immune system and in inflammatory situations. In addition to KLF2 and KLF4, the roles of KLF10 and KL13 in lymphocytes are briefly discussed.

Original language	English (US)
Title of host publication	The Biology of Krüppel-like Factors
Publisher	Springer Japan
Pages	95-106
Number of pages	12
ISBN (Print)	9784431877745
DOIs	https://doi.org/10.1007/978-4-431-87775-2_7
State	Published - 2009

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title = "Roles of Kr{\"u}ppel-like factors in lymphocytes",

abstract = "Several family members of Kr{\"u}ppel-like factors (KLFs) are found in lymphocytes, and their expression is tightly regulated during development and differentiation. The related factors KLF2 and KLF4 have been suggested to promote lymphocyte quiescence by inducing withdrawal of cells from the cell cycle. Although the physiological role of KLF2 in cell cycle control in lymphocytes is currently unclear, it is potentially due to redundancy between related KLFs. On the other hand, there is growing evidence that individual KLFs regulate migration of lymphocytes (and other cells) during normal homeostasis of the immune system and in inflammatory situations. In addition to KLF2 and KLF4, the roles of KLF10 and KL13 in lymphocytes are briefly discussed.",

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doi = "10.1007/978-4-431-87775-2_7",

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AU - Hogquist, Kristin A.

AU - Jameson, Stephen C.

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AB - Several family members of Krüppel-like factors (KLFs) are found in lymphocytes, and their expression is tightly regulated during development and differentiation. The related factors KLF2 and KLF4 have been suggested to promote lymphocyte quiescence by inducing withdrawal of cells from the cell cycle. Although the physiological role of KLF2 in cell cycle control in lymphocytes is currently unclear, it is potentially due to redundancy between related KLFs. On the other hand, there is growing evidence that individual KLFs regulate migration of lymphocytes (and other cells) during normal homeostasis of the immune system and in inflammatory situations. In addition to KLF2 and KLF4, the roles of KLF10 and KL13 in lymphocytes are briefly discussed.

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ER -

Roles of Krüppel-like factors in lymphocytes

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