Role of vasoconstrictor mechanisms in the control of left ventricular performance of the normal and damaged heart

Jay N Cohn; FACC Iwao Mashiro; T. Barry Levine; Jawahar Mehta

doi:10.1016/0002-9149(79)90238-8

Role of vasoconstrictor mechanisms in the control of left ventricular performance of the normal and damaged heart

Jay N Cohn, FACC Iwao Mashiro, T. Barry Levine, Jawahar Mehta

Medicine - Cardiology Division

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The effect on the left ventricle of changes in the state of the arterial vasculature is best identified by utilizing calculations of pulsatile rather than steady flow phenomena. Impedance is the most satisfactory term to describe this effect. The normal ventricle compensates for changes in impedance largely by changes in preload, but the damaged heart loses this compensatory ability and its stroke volume becomes inversely related to outflow resistance. Patients with heart failure behave in a similar fashion and pharmacologic vasodilation may induce marked improvement in left ventricular pump function. Inappropriate vasoconstriction in heart failure may result from stimulation of the sympathetic or renin-angiotensin system. Early experience with converting enzyme inhibitors suggests that blockade of the formation of angiotensin II may be a useful means of treating some patients with heart failure.

Original language	English (US)
Pages (from-to)	1019-1022
Number of pages	4
Journal	The American Journal of Cardiology
Volume	44
Issue number	5
DOIs	https://doi.org/10.1016/0002-9149(79)90238-8
State	Published - Oct 22 1979

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1016/0002-9149(79)90238-8

Find It

Find It at U of M Libraries

Cite this

@article{ff99a95a74bc4a6e8bb8e3354b6b69df,

title = "Role of vasoconstrictor mechanisms in the control of left ventricular performance of the normal and damaged heart",

abstract = "The effect on the left ventricle of changes in the state of the arterial vasculature is best identified by utilizing calculations of pulsatile rather than steady flow phenomena. Impedance is the most satisfactory term to describe this effect. The normal ventricle compensates for changes in impedance largely by changes in preload, but the damaged heart loses this compensatory ability and its stroke volume becomes inversely related to outflow resistance. Patients with heart failure behave in a similar fashion and pharmacologic vasodilation may induce marked improvement in left ventricular pump function. Inappropriate vasoconstriction in heart failure may result from stimulation of the sympathetic or renin-angiotensin system. Early experience with converting enzyme inhibitors suggests that blockade of the formation of angiotensin II may be a useful means of treating some patients with heart failure.",

author = "Cohn, {Jay N} and Mashiro, {FACC Iwao} and Levine, {T. Barry} and Jawahar Mehta",

year = "1979",

month = oct,

day = "22",

doi = "10.1016/0002-9149(79)90238-8",

language = "English (US)",

volume = "44",

pages = "1019--1022",

journal = "The American Journal of Cardiology",

issn = "0002-9149",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Role of vasoconstrictor mechanisms in the control of left ventricular performance of the normal and damaged heart

AU - Cohn, Jay N

AU - Mashiro, FACC Iwao

AU - Levine, T. Barry

AU - Mehta, Jawahar

PY - 1979/10/22

Y1 - 1979/10/22

N2 - The effect on the left ventricle of changes in the state of the arterial vasculature is best identified by utilizing calculations of pulsatile rather than steady flow phenomena. Impedance is the most satisfactory term to describe this effect. The normal ventricle compensates for changes in impedance largely by changes in preload, but the damaged heart loses this compensatory ability and its stroke volume becomes inversely related to outflow resistance. Patients with heart failure behave in a similar fashion and pharmacologic vasodilation may induce marked improvement in left ventricular pump function. Inappropriate vasoconstriction in heart failure may result from stimulation of the sympathetic or renin-angiotensin system. Early experience with converting enzyme inhibitors suggests that blockade of the formation of angiotensin II may be a useful means of treating some patients with heart failure.

AB - The effect on the left ventricle of changes in the state of the arterial vasculature is best identified by utilizing calculations of pulsatile rather than steady flow phenomena. Impedance is the most satisfactory term to describe this effect. The normal ventricle compensates for changes in impedance largely by changes in preload, but the damaged heart loses this compensatory ability and its stroke volume becomes inversely related to outflow resistance. Patients with heart failure behave in a similar fashion and pharmacologic vasodilation may induce marked improvement in left ventricular pump function. Inappropriate vasoconstriction in heart failure may result from stimulation of the sympathetic or renin-angiotensin system. Early experience with converting enzyme inhibitors suggests that blockade of the formation of angiotensin II may be a useful means of treating some patients with heart failure.

UR - http://www.scopus.com/inward/record.url?scp=0018639302&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018639302&partnerID=8YFLogxK

U2 - 10.1016/0002-9149(79)90238-8

DO - 10.1016/0002-9149(79)90238-8

M3 - Article

C2 - 386761

AN - SCOPUS:0018639302

SN - 0002-9149

VL - 44

SP - 1019

EP - 1022

JO - The American Journal of Cardiology

JF - The American Journal of Cardiology

IS - 5

ER -

Role of vasoconstrictor mechanisms in the control of left ventricular performance of the normal and damaged heart

Abstract

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this