Role of Topoisomerase Mutations and Efflux in Fluoroquinolone Resistance of Bacteroides fragilis Clinical Isolates and Laboratory Mutants

Vito Ricci, Marnie L. Peterson, John C. Rotschafer, Hannah Wexler, Laura J.V. Piddock

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Twelve laboratory mutants and 32 ciprofloxacin-resistant isolates of Bacteroides fragilis were examined for the mechanism(s) of fluoroquinolone resistance. Five mutants had mutations in gyrA. One mutant and two clinical isolates contained a mutation in gyrB. Eight mutants and five clinical isolates accumulated significantly less ciprofloxacin than did wild-type isolates; the mutants and clinical isolates were restored to wild-type characteristics when carbonyl cyanide m-chlorophenylhydrazone was used.

Original languageEnglish (US)
Pages (from-to)1344-1346
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume48
Issue number4
DOIs
StatePublished - Apr 2004

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